James Duke

James Duke may refer to:


 * James Buchanan Duke (1856–1925), American tobacco and electric power magnate
 * SS James B. Duke a Liberty ship
 * James A. Duke (1929–2017), ethnobotanist
 * Sir James Duke, 1st Baronet (1782–1873), British Member of Parliament
 * Sir James Duke, 2nd Baronet, of the Duke baronets
 * James "Red" Duke (1928–2015), Houston, Texas, doctor
 * James Duke (footballer), Scottish footballer