James Durham

James Durham may refer to:


 * James Durham (baseball) (1881–1949), pitcher in Major League Baseball
 * James Durham (minister), Church of Scotland minister
 * James R. Durham (1833–1904), Union Army officer and Medal of Honor recipient
 * James J. Durham (1849–1920), Baptist minister in South Carolina and the founder of Morris College
 * Jim Durham (1947–2012), American sportscaster
 * James Derham (1762–1802?), also known as James Durham, the first African American to formally practice medicine in the United States