James Gamble

James Gamble may refer to:


 * James Gamble (industrialist) (1803–1891), U.S.-based Irish soapmaker and industrialist; co-founder of Procter & Gamble Company
 * James Gamble (congressman) (1809–1883), U.S. Representative from Pennsylvania
 * James Gamble (telegraph) (18??–?), Piedmont resident, and builder of the first telegraph in California
 * James Sykes Gamble (1847–1925), English botanist
 * James Fulton Gamble, Northern Irish politician
 * James Gamble (1995–2015), Canadian co-conspirator responsible for the Halifax mass shooting plot