James Hepburn

James Hepburn may refer to:


 * James Hepburn (bishop) (died 1524), Bishop of Moray
 * James Hepburn, 4th Earl of Bothwell (c. 1534–1578), Scottish ruler, Duke of Orkney, the third husband of Mary, Queen of Scots
 * Bonaventure Hepburn (James Hepburn, 1573–1621), Scottish orientalist
 * James Hepburn Campbell (1820–1895), American politician and diplomat
 * James Curtis Hepburn (1815–1911), American missionary
 * James de Congalton Hepburn (1878–1955), Canadian MPP
 * Jamie Hepburn (born 1979), Scottish politician
 * James Hepburn (ornithologist) (1811–1869), English ornithologist
 * Jock Hepburn (c. 1860–?), birth name James, Scottish footballer (Alloa Athletic and Scotland)
 * James Hepburn (golfer) (1876–1945), golfer from Scotland