James Little

James Little may refer to:


 * James Little (American politician), Wisconsin State Assemblyman
 * James Little (British politician) (1868–1946), unionist politician in Northern Ireland
 * James Little (physician) (1837–1916), Irish physician
 * James-Little Ecological Reserve
 * Jimmy Little (1937–2012), Australian Aboriginal musician, singer and songwriter
 * Jim Little (businessman), CEO of Ottawa Senators, 2020
 * Jimmy Little (carpenter) (born 1976), carpenter, stagehand and TV personality
 * James Little (shepherd) (1834–1921), New Zealand shepherd and sheep breeder
 * James Little (unionist), American labor union leader
 * James Lewis Little (1871–1967), schooner captain and politician in Newfoundland
 * James Little (painter) (born 1952), American painter