James Mathews

James Mathews may refer to:


 * James Mathews (American politician) (1805–1887), member of the US House of Representatives from Ohio
 * James Mathews (Australian politician) (1865–1934), Australian politician
 * James Mathews (rugby league) (1968–1992), Australian rugby player
 * James M. Mathews, Chancellor of New York University (NYU)
 * James McFarlane Mathews (1785–1870), American clergyman in New York City