James Reilly

James Reilly may refer to:
 * James Reilly (Canadian politician) (1835–1909), Canadian businessman and Mayor of Calgary
 * James Reilly (Irish politician) (born 1955), Irish Fine Gael politician
 * James Reilly (swimmer) (1890–1962), American swimmer
 * James Bernard Reilly (1845–1924), U.S. Representative from Pennsylvania
 * James E. Reilly (1948–2008), American television scriptwriter
 * James F. Reilly (born 1954), American astronaut and geologist, director of the U.S. Geological Survey
 * James Marshall Reilly (born 1981), American entrepreneur, author and public speaker
 * James W. Reilly (1828–1905), American Civil War general in the Union Army and Ohio state representative
 * Jim Reilly (born 1957), drummer for punk band Stiff Little Fingers
 * Jim Reilly (American football) (1948–1994), American football player
 * Jim Reilly (Gaelic footballer) (1924–2013), Irish footballer
 * Jim Reilly (Illinois politician) (1945–2022), American politician from Illinois
 * Joe Reilly (baseball) (James Reilly, 1861–?), American baseball player