James Smyth

James Smyth may refer to:


 * Sir James Smyth (English MP) (c. 1621–1681), English Member of Parliament for Exeter and Camelford
 * Sir James Smyth, 1st Baronet (c. 1686–1717), Sheriff of Sussex 1714–15
 * James Smyth (Irish MP) (c. 1716–1771), Irish Member of Parliament for Antrim and Dundalk
 * James Smyth (priest) (1683–1799), Anglican priest in Ireland
 * James Carmichael Smyth (physician) (1742–1821), Scottish medical writer and physician to King George III
 * Sir James Carmichael-Smyth, 1st Baronet (1779–1838), his son, British colonial administrator
 * James Adger Smyth (1837–1920), mayor of Charleston, South Carolina
 * Red Smyth (James Daniel Smyth, 1893–1958), American baseball player
 * James G. Smyth (fl. mid-20th century), American politician
 * Jimmy Smyth (hurler) (1931–2013), Irish hurler