James Spence

James Spence may refer to:


 * James Spence (sailor) (1875–1946), Olympic sailor from the Great Britain
 * James Spence (surgeon) (1812–1882), Scottish surgeon
 * James Calvert Spence (1892–1954), British paediatrician
 * James Houston Spence (1867–1939), Canadian lawyer and Senator
 * James MacDonald Spence, lawyer and Justice of the Ontario Superior Court of Justice
 * Jamie Spence (born 1963), English golfer
 * James Spence, Scottish author of the 2009 book Silly Beggar