James Vaughan

James Vaughan may refer to:


 * James Vaughan (priest), Dean of Achonry, Ireland, from 1662 to 1683
 * James Vaughan (magistrate) (1814-1906), British magistrate
 * James David Vaughan (1864–1941), American musician
 * James Churchill Vaughan (1893–1937), Nigerian physician
 * James H. Vaughan (1934–1996), Canadian politician
 * James J. Vaughan (1870–1935), American composer
 * James Vaughan (footballer, born 1986), English right-back
 * James Vaughan (footballer, born 1988), English footballer for Tranmere Rovers
 * James Vaughan (police officer), chief constable of Dorset Police
 * James Vaughan, creator of the video game Plague Inc.