James Wayne

James Wayne may refer to:


 * James Moore Wayne (1790–1867), U.S. Supreme Court Justice and U.S. Representative
 * SS James M. Wayne, a Liberty ship
 * James Wayne (R&B musician) (1920–1978), American rhythm and blues musician who also recorded as James Waynes and "Wild Willie" Wayne
 * Jimmy Wayne (born 1972), American country musician
 * Jimmy Wayne (album)
 * Jim Wayne, member of the Kentucky House of Representatives