James Wylie

James Wylie may refer to:
 * Sir James Wylie, 1st Baronet (1768–1854), Scottish physician
 * James Aitken Wylie (1808–1890), Scottish historian of religion and Presbyterian minister
 * James Hamilton Wylie (1844–1914), British historian and author
 * James Owens Wylie (1845–1935), Irish lawyer and judge
 * Jim Wylie (1887–1956), New Zealand rugby union player