James Wynne

James Wynne may refer to:
 * James Wynne (rugby league) (born 1976), Australian rugby player for France
 * James Wynne (rower) (born 1937), American Olympian
 * James J. Wynne, American physicist
 * James Wynne (died 1709), soldier and MP for County Leitrim (Parliament of Ireland constituency)
 * James Wynne (died 1748), MP for County Sligo (Parliament of Ireland constituency)