Jamestown Historic District

Jamestown Historic District may refer to:


 * Jamestown Historic District (Jamestown, North Carolina), listed on the National Register of Historic Places in Guilford County, North Carolina
 * Jamestown Historic District (Jamestown, North Dakota), listed on the National Register of Historic Places in Stutsman County, North Dakota
 * Jamestown Historic District (Florence, South Carolina), listed on the National Register of Historic Places in Florence County, South Carolina