Jessie Smith

Jessie Smith may refer to:


 * Jessie Payne Margoliouth (1856–1933), née Smith, Syriac scholar
 * Jessie Willcox Smith (1863–1935), American illustrator
 * Jessie Evans Smith (born Jessie Ella Evans; 1902–1971), wife of Joseph Fielding Smith
 * Jessie Maye Smith (1907–2005), American ornithologist
 * J. L. Smith (born Jessie L. Smith), American baseball pitcher
 * Jessie Carney Smith (born 1930), American librarian and educator
 * Jessie Smith (singer) (1941–2021), American R&B vocalist