Joe O'Brien

Joe O'Brien may refer to:


 * Joe O'Brien (American football) (born 1972), American football player / coach
 * Joe O'Brien (basketball) (born 1955), American basketball coach
 * Joe O'Brien (cyclist) (fl. 1959–1960), Irish cyclist
 * Joe O'Brien (footballer) (1875–?), Scottish footballer
 * Joe O'Brien (harness racing) (1917–1984), American driver, trainer and owner
 * Joe O'Brien (politician), Irish Green Party politician and TD in the 32nd Dáil