John Cain

John Cain may refer to:


 * John Cain (34th Premier of Victoria) (1882–1957), Australian politician
 * John Cain (41st Premier of Victoria) (1931–2019), Australian politician, son of the above
 * John Cain (lawyer), Victorian Government Solicitor (2006–2011), grandson of the 34th and son of the 41st premier of Victoria
 * John Cain (rugby union), English rugby union player
 * John Edward Cain (1887–1981), American politician
 * John J. Cain (1861–1937), American mayor of Bayonne, New Jersey
 * John Paul Cain (1936–2017), American golfer
 * John Vincent Cain (1907–1940), British fraudster
 * Johnny Cain (1908–1977), American football player, college sports coach and administrator