John Isham

John Isham may refer to:
 * Sir John Isham (1582–1651), High Sheriff of Northamptonshire
 * John Isham (composer) (1680–1726), English composer and organist
 * John Isham Farmstead, on the National Register of Historic Places listings in Lucas County, Ohio
 * John William Isham (1866–?), American vaudeville impresario