John Mayo

John Mayo may refer to:


 * John Mayo (minister) (died 1676), Puritan minister in pre-revolutionary Boston, Massachusetts
 * John Mayo (physician) (1761–1818), English doctor
 * John Mayo (cricketer) (1822–1899), English cricketer
 * John C. C. Mayo (1864–1914), American entrepreneur, educator and politician
 * John S. Mayo (born 1930), American engineer