John Semple

John Semple may refer to:
 * John Semple (minister) (c. 1602–c. 1677), Ulster-Scots Presbyterian minister and Scots Worthy
 * John Semple (architect) (1801–1882), Irish architect
 * John Semple (footballer) (1889–?), Scottish footballer
 * Jock Semple (1903–1988), Scots-American sports official and trainer
 * John Greenlees Semple (1904–1985), British mathematician
 * John Semple (civil servant) (born 1940), former head of the Northern Ireland Civil Service
 * John W. Semple (born 1959), Canadian medical researcher
 * John C. Semple, American botanist