John Spence

John Spence may refer to:


 * John Spence (frogman) (1918–2013), American World War II veteran, first American combat frogman
 * John Spence (musician) (1969–1987), founding member of the band No Doubt
 * John Spence (politician) (1920–1986), British Conservative MP 1970–1986
 * John Spence (sailor) (1875–1946), British sailor, won silver medal at 1908 Summer Olympics
 * John Spence (scientist) (1929–2013), Trinidadian botanist and politician
 * John C. H. Spence (1946–2021), Richard Snell Professor of Physics at Arizona State University
 * John S. Spence (1788–1840), American Senator from Maryland
 * John Selby Spence (bishop) (1909–1973)
 * John David Spence (born 1944), Canadian medical doctor, medical researcher and professor
 * John Brodie Spence (c. 1824–1902), banker and politician in South Australia
 * John Spence (footballer), footballer for Sunderland
 * John Spence (zoo director), South Africa
 * John P. Spence (politician) (1905-1981) Ontario politician
 * John Spence (entrepreneur), a British-born founder and chairman of the Karma Group