José Santiago

José Santiago may refer to:


 * José Santiago (1950s pitcher) (1928–2018), Puerto Rican pitcher in Major League Baseball, 1954–1956
 * José Santiago (1960s pitcher) (born 1940), Puerto Rican pitcher in Major League Baseball, 1963–1970
 * José Santiago (2000s pitcher) (born 1974), Puerto Rican pitcher in Major League Baseball, 1997–2005
 * José Avilés Santiago, Puerto Rican politician; mayor of Moca 2001–2021
 * Jose L. Santiago, American politician
 * José Luis Santiago Vasconcelos (1957–2008), Mexican civil servant killed in an aviation accident
 * José Turiano Santiago (1875–1942?), Filipino patriot in the 1896 Philippine Revolution