José Vargas

José Vargas or Jose Vargas may refer to:
 * José Vargas (baseball) (1905–?), Cuban baseball player
 * José Vargas (basketball) (born 1963), Dominican basketball player
 * Jose "Joe" Vargas, American YouTuber also known as "Angry Joe"
 * Jose Antonio Vargas (born 1981), journalist, filmmaker and immigration rights activist
 * José Augusto Vargas, Peruvian politician
 * José Gregorio Vargas (born 1982), Venezuelan basketball player
 * José Lino Vargas (born 1930), Chilean politician
 * José María Vargas (1786–1854), President of Venezuela from 1835 to 1836