Joseph O'Brien

Joseph O'Brien may refer to:


 * Joseph Patrick O'Brien (born 1993), Irish jockey and racehorse trainer
 * Joseph O'Brien (singer), American singer and songwriter
 * Joseph C. O'Brien (born 1965), mayor of Worcester, Massachusetts, USA
 * Joseph J. O'Brien (1897–1953), U.S. congressman from New York
 * Joseph Leonard O'Brien (1895–1973), lieutenant governor of New Brunswick
 * Joseph O'Brien (rower), Australian rower
 * Joe O'Brien (basketball) (born 1955), basketball player
 * Joe O'Brien (footballer) (1875 – after 1906), Scottish football full back
 * Joey O'Brien (born 1986), Irish international and former Bolton Wanderers footballer