KSC

KSC may refer to:


 * Kalinga language (ISO 639 language code )
 * Karlsruher SC, a German association football club, based in Karlsruhe, Baden-Württemberg
 * Keene State College, New Hampshire, US
 * Kelsey-Seybold Clinic, Houston, US, NASA-affiliated
 * Kennedy Space Center, Cape Canaveral, Florida, US
 * Kenya Social Congress
 * Kilogram-force per square centimetre
 * Knights of Saint Columba, a UK Catholic lay society
 * Knights of the Southern Cross, an Australian Catholic lay society
 * Košice International Airport (IATA airport code ), Košice, Slovakia
 * Kurtis Sport Car, US
 * Communist Party of Czechoslovakia (Czech and Slovak: Komunistická strana Československa, KSČ), 1921-1992