KSIX

KSIX may refer to:


 * KSIX (AM), a radio station (1230 AM) licensed to serve Corpus Christi, Texas, United States
 * KSIX-TV, a television station (channel 22, virtual 13) licensed to serve Hilo, Hawaii, United States
 * KFVE, a television station (channel 25/PSIP 6) licensed to serve Kailua-Kona, Hawaii, which held the call sign KSIX-TV in 2020
 * KZTV, a television station (channel 10) licensed to serve Corpus Christi, Texas, which held the call sign KSIX-TV from 1956 to 1957