Keefer

Keefer may refer to:


 * Charles Keefer (1852–1932) was one of Canada's pioneering engineers
 * Chester Keefer (1897–1972), American physician, medical researcher, and medical school dean
 * Don Keefer (1916–2014), American actor originally from Pennsylvania
 * Francis Henry Keefer (1860–1928), Canadian lawyer and politician
 * Janice Kulyk Keefer (born 1952), Canadian novelist and poet
 * John Keefer Mahony (1911–1990), Canadian recipient of the Victoria Cross
 * Keefer-Brubaker Farm (Oscar Fogle Farm), a historic home and farm complex located at Taneytown, Carroll County, Maryland, United States
 * Mel Keefer (1926–2022), American artist
 * Philip B. Keefer (1875–1949), United States Navy sailor and a recipient the Medal of Honor for his actions during the Spanish–American War
 * Thomas Keefer (1821–1915), Canadian civil engineer
 * Keefers, British Columbia, a railway point and ghost town in British Columbia, Canada