Knob Creek (Stouts Creek tributary)

Knob Creek is a stream in Iron and St. Francois counties in the U.S. state of Missouri. It is a tributary of Stouts Creek.

The stream headwaters arise on the west flank of Oak Mountain at an elevation of 1400 feet. The stream flows west-southwest to enter the adjacent valley near Lopez about one mile south of Middlebrook in the southwest corner of St. Francois County. The stream enters Iron County and turns south-southeast and flows past Pilot Knob and Ironton to its confluence with Stouts Creek.

The source area is at 37.65389°N, -90.63306°W and the confluence is at 37.60028°N, -90.61417°W.

Knob Creek was named for a summit along its course called Pilot Knob.