L'isola dei famosi season 16

L'isola dei famosi 16 is the sixteenth season of the reality television L'isola dei famosi and the Italian version of the reality show franchise Survivor, aired in prime time on Canale 5 from 21 March to 27 June 2022. It was the seventh consecutive edition broadcast by Mediaset, hosted by Ilary Blasi for the second consecutive year, supported in the studio by commentators Nicola Savino and Vladimir Luxuria, and with the participation of the correspondent Alvin. It lasted 99 days, had 32 castaways and 25 episodes and was held in Cayos Cochinos (Honduras). The motto of this edition was L'isola dei famosi 2022: Tutto può cambiare!.

The stories of the castaways were broadcast by Canale 5 in prime time with a double weekly appointment (Mondays and Thursdays up to the eighth episode, followed by the ninth to the twentieth episode on Mondays and Fridays and finally from the twenty-first to the twenty-fifth episode only on Mondays), while the transmission of the daily strips in the day-time was entrusted to Canale 5 and Italia 1 from Monday to Friday. Furthermore, the day-time was broadcast on La5 and Mediaset Extra with the addition of unpublished material with the title of ''L'isola dei famosi. Extended Edition'', the duration of which is 185 minutes.

The edition was won by Nicolas Vaporidis, who was awarded the prize pool of €100,000.

Contestants
The age of the contestants refers to the time of landing on the island.

Nominations table
Legend {{legend|#FBF373|Leader: the contestant is the challenge winner / part of the winning duo and immune; they have to pick a contestant / duo that will be directly nominated}} {{legend|#FFC0CB| The contestant is immune}}

