LAGLIDADG RNA motifs

LAGLIDADG RNA motifs are conserved RNA structures that were discovered by bioinformatics. These RNA motifs are associated with genes that encode endonucleases of the LAGLIDADG variety. Although group I introns are often present in self-replicating elements that use LAGLIDADG endonucleases, the known LAGLIDADG RNA motifs appear too small and structurally simple to function as a self-splicing intron.

A LAGLIDADG-1 motif RNA is predicted in the fungus Trametes cingulata as well as many metagenomic sequences, which presumably are derived from other fungi. LAGLIDADG-2 motif RNAs are found in Halobacteria. It is ambiguous whether LAGLIDADG-1 RNAs function as cis-regulatory elements or whether they operate in trans.