La Serna

(La) Serna may refer to:


 * La Serna, Palencia, Castile and León, Spain
 * La Serna de Iguña, Cantabria, Spain
 * La Serna del Monte, Community of Madrid, Spain
 * La Serna High School, Whittier, California
 * Serna, a village development committee in Nepal
 * Serna (surname)
 * Serna-class landing craft, a series of Russian landing craft