Leatherwood Creek (St. Francis River tributary)

Leatherwood Creek is a stream in Iron and Madison County in the U.S. state of Missouri. It is a tributary of St. Francis River.

The stream headwaters arise in southeastern Iron County and it flows southeast into western Madison County parallel to Missouri Route C past the community of Jewett to its confluence with the St. Francis about four miles southwest of Rock Pile Mountain.

The source area is at 37.4275°N, -90.55639°W and the confluence is at 37.38139°N, -90.47694°W.

Leatherwood Creek was named for leatherwood near its course.