Leo O'Brien

Leo O'Brien may refer to:


 * Leo O'Brien (actor) (1970–2012), American television and film actor
 * Leo O'Brien (cricketer) (1907–1997), Australian cricketer
 * Leo F. O'Brien (1924-1968), American politician, member of the Illinois House of Representatives
 * Leo P. O'Brien (1893–1968), American politician, member of the Wisconsin State Senate
 * Leo W. O'Brien (1900–1982), American politician, Representative from New York