Levopropylhexedrine

Levopropylhexedrine (Eventin) is an adrenergic alkylamine that was used as an anorectic in Germany and was first patented for medical use by Smith Kline & French in 1947. It has also been used in the anticonvulsant preparation barbexaclone in combination with phenobarbital to offset sedation. Levopropylhexedrine is the levorotatory S-enantiomer of propylhexedrine. The dextrorotatory counterpart is known as dextropropylhexedrine.

Synthesis
The enantiopure synthesis of levopropylhexedrine may be accomplished in a two step reaction. The first step is the Wenker synthesis of the relevant aziridine. The second step is the simple catalytic hydrogenation of the propylhexedrine-aziridine.
 * Synthesis of levopropylhexedrine.svg