Lewis Payne

Lewis Payne may refer to:
 * Lewis Powell (conspirator) (1844–1865), also known as Lewis Payne, American Confederate soldier who attempted to assassinate William H. Seward.
 * Lewis F. Payne Jr. (born 1945), American politician from Virginia
 * Lewis S. Payne (1819–1898), American merchant, Union Army officer, and politician from New York
 * Lewis Payne (footballer) (born 2004), English association footballer