Lewis and Clark Highway

Lewis and Clark Highway may refer to:


 * Lewis and Clark Trail, a named highway approximating the path of Lewis and Clark in 1804-1806
 * Lewis and Clark Highway (Montana), a named highway in Montana

Lewis and Clark Highway may also refer to:


 * Lewis and Clark National Historic Trail, a route roughly marking the path of Lewis and Clark's journey
 * Northwest Passage Scenic Byway, a scenic byway in Idaho
 * Lewis and Clark Back Country Byway, a scenic byway in Idaho
 * Sacajawea Historic Byway, a scenic byway in Idaho
 * Sakakawea Scenic Byway, a scenic byway in North Dakota
 * Lewis & Clark Scenic Byway, a scenic byway in Nebraska