Limulus clotting enzyme

Limulus clotting enzyme (, clotting enzyme) is an enzyme. This enzyme catalyses the following chemical reaction:


 * Selective cleavage of -Arg18- and -Arg47- bonds in coagulogen to form coagulin and fragments

This enzyme is present in the hemocyte granules of horseshoe crabs Limulus and Tachypleus. In the immunity-related clotting pathways of these organisms, it is the final enzyme responsible for the activation of coagulin.