Lipoate–protein ligase

Lipoate–protein ligase (, LplA, lipoate protein ligase, lipoate–protein ligase A, LPL, LPL-B) is an enzyme with systematic name ATP:lipoate adenylyltransferase. This enzyme catalyses the following chemical reaction


 * (1) ATP + lipoate $$\rightleftharpoons$$ diphosphate + lipoyl-AMP
 * (2) lipoyl-AMP + apoprotein $$\rightleftharpoons$$ protein N6-(lipoyl)lysine + AMP

This enzyme requires Mg2+ as a cofactor.