List of Billboard Argentina Hot 100 number-one singles of 2021

The Billboard Argentina Hot 100 is a chart that ranks the best-performing songs in the Argentina. Its data, published by Billboard Argentina and Billboard magazines and compiled by Nielsen SoundScan and BMAT/Vericast, is based collectively on each song's weekly physical and digital sales, as well as the amount of airplay received on Argentine radio stations and TV and streaming on online digital music outlets.