List of Billboard Global 200 top-ten singles in 2021

This is a list of singles that charted in the top ten of the Billboard Global 200, an all-genre singles chart, in 2021.

Top-ten singles
Key
 * – indicates single's top 10 entry was also its Global 200 debut
 * – indicates Best performing song of the year
 * (#) – 2021 Year-end top 10 single position and rank