List of Billboard Latin Pop Airplay number ones of 2000

Latin Pop Airplay (formerly designated as Hot Latin Pop Tracks) is a chart published by Billboard magazine that ranks the top-performing songs (regardless of genre or language) on Latin pop radio stations in the United States, based on weekly airplay data compiled by Nielsen's Broadcast Data Systems. It is a subchart of Hot Latin Songs (formerly known as Hot Latin Tracks), which lists the best-performing Spanish-language songs in the country. In 2000, eight songs topped the chart, in 52 issues of the magazine.

At the start of the year, singer-songwriter Ricardo Arjona's song "Desnuda" was at number one, where it spent 12 consecutive weeks before being replaced by "Dónde Está el Amor", performed by Charlie Zaa, in the issue dated March 25. Arjona returned to the top of the chart with his next single, "Cuando", which spent seven weeks at number one between September and November; he was the only artist with more than one chart-topper during the year.

"A Puro Dolor" by Son by Four was the best-performing song of 2000 on both the Latin pop and Hot Latin Songs charts. It spent a total of 19 non-consecutive weeks at number one on the airplay chart, breaking the record for the most weeks at number one set by Cristian Castro's song "Vuélveme a Querer" in 1995. Latin pop stations received the ballad rendition of the track, propelling its ascent to popularity subsequent to its inclusion in the Mexican soap opera La vida en el espejo (1999). Despite this level of success, it would be the band's only chart-topper.

Thalía achieved her first chart-topper with "Entre el Mar y una Estrella" as did Giselle with the ballad version of "Júrame". Chayanne had the final number-one song of the year with "Yo Te Amo" which spent eight weeks at this position.