List of Major League Baseball career losses leaders

In the sport of baseball, a loss is a statistic credited to the pitcher of the losing team responsible for the run that gives the opposing team the lead with which the game is won (the go-ahead run). The losing pitcher is the pitcher responsible for the go-ahead run to reach base for a lead that the winning team never relinquishes. If a pitcher allows a run which gives the opposing team the lead, his team comes back to lead or tie the game, and then the opposing team regains the lead against a subsequent pitcher, the earlier pitcher does not get the loss.

Cy Young holds the MLB loss record with 316; Pud Galvin is second with 308. Young and Galvin are the only players to earn 300 or more losses.