List of Missouri high schools by athletic conferences

The following lists Missouri high schools and the athletic conferences in which they compete. Under the current system used by the Missouri State High School Activities Association some conference member teams may also compete in the same playoff district while others are in districts with non-conference members. As a general rule most conferences contain schools within their region and of similar class size, the class based on school enrollment.

Clarence Cannon
Departing members are in red.

Brookfield will join the Grand River Conference for the 2024-25 season.

Crossroads
The Kansas members of the conference withdrew to form a new league within the Kansas State High School Activities Association.

Kaysinger
Departing members are in red.

Tipton will leave the Kaysinger Conference for the new Central State 8 Conference for the 2024-25 season.

Lewis & Clark
Departing members are in red.

In the 2024-25 season, Fayette and Harrisburg will leave this conference along with Eugene, Linn, New Bloomfield, Russellville, and South Callaway from the Show-Me Conference to form a new Central Missouri conference. The conference will be called the Central State 8 Conference.

Marceline will leave this conference to join the Grand River Conference.

North Shelby will cease being an independent school and join the Lewis and Clark Conference in the 2024-25 season to make up for the loss of members.

Metro (Kansas City) Christian Athletic Association
Two former members, Heritage Christian Academy (Olathe, KS) and Cair Paravel Latin (Topeka, KS) are now full members of the Kansas State High School Activities Association.

Metro (St. Louis) ?? League
This League appears to be defunct.

East Division
Carrollton and Richmond have been conference members since its founding in 1928. Lexington joined in 1934 and Lafayette County (Higginsville) in 1937.

West Division
Grain Valley left the conference at the end of the 2017-18 school year and joined the Suburban Kansas City Conference. Warrensburg replaced Grain Valley.

Center and Clinton were added beginning in the 2020-21 school year.

Excelsior Springs departed after the 2021-22 school year and followed Grain Valley to the Suburban Conference.

Independents
The following lists schools that are independents, meaning they do not belong to or compete in any of the athletic conferences above. However they do compete against other schools in Missouri (and sometimes surrounding states) on a non-conference basis. Independents are included in the MSHSAA playoff system based on a District assignment separate from any athletic conference.

Departing members are in red.