List of Resident Evil characters

This is a list of Resident Evil characters, which includes playable and recurring characters that were introduced in Resident Evil, a series of survival horror video games.

Appearances
P - Playable character (campaign/unlockable-mini campaign) P* - Playable character (minigame/DLC)

Chris Redfield
Chris is first introduced in Resident Evil as a pointman for the Raccoon City Police Department's S.T.A.R.S. Alpha Team. In the fight against Bio-Organic Weapons (B.O.W), Chris becomes a co-founder of the B.S.A.A, a counter terrorism organization dedicated to fighting the threat of B.O.W's unleashed by criminal or terrorist elements on a global scale.

Jill Valentine
Jill is first introduced in Resident Evil as a member of the Raccoon Police departments's S.T.A.R.S. Alpha Team. Jill is a co-founder of the B.S.A.A, a counter terrorism organization dedicated to fighting the threat of Bio-Organic Weapons (B.O.W) unleashed by criminal or terrorist elements on a global scale.

Albert Wesker
Albert Wesker is first introduced in Resident Evil as a triple agent who poses as the leader of S.T.A.R.S. team, and in subsequent sequels as a high-ranking Umbrella scientist who undermines the pharmaceutical organization on behalf of a rival company with the goal of global saturation.

Rebecca Chambers
Rebecca Chambers is first introduced in Resident Evil as a supporting character and field medic of the S.T.A.R.S team. Rebecca also appears as the co-protagonist of Resident Evil Zero along with Billy Coen.

Leon Scott Kennedy
Leon Kennedy is first introduced in Resident Evil 2 as a rookie police officer in the Raccoon City Police Department (R.P.D) who escapes from Raccoon City following a zombie outbreak. He is revealed in Resident Evil 4 to have been recruited by the US federal government and trained to become an elite agent who reports directly to the president of the United States.

Claire Redfield
Claire is first introduced in Resident Evil 2 as a college student looking for her older brother Chris Redfield. She is depicted in subsequent sequels as a worker for a human rights organization called TerraSave, which provides relief and aid to victims of bioterrorism.

Ada Wong
Ada Wong is first introduced in Resident Evil 2 as a corporate spy and mercenary. Her clientele has included Albert Wesker and a mysterious organization known only as the "Agency". Ada is occasionally featured as the main character of select scenarios or campaigns in the franchise's video games.

Billy Coen

 * Voiced by (English): James Kee (RE0), Steve Van Wormer (The Umbrella Chronicles)
 * Voiced by (Japanese): Katsuyuki Konishi (RE0 HD Remaster)

Billy Coen (ビリー・コーエン) is the co-protagonist of Resident Evil Zero along with Rebecca Chambers. He is first mentioned in a police report filed by Chambers that can be found in the Nintendo 64 version of Resident Evil 2, foreshadowing the events of the prequel. A former Second Lieutenant in the United States Marine Corps Force Reconnaissance, Billy is sentenced to death by a military court for massacring 23 people in murky circumstances during a mission in Africa. Billy's flashbacks imply he is innocent and the victim of a cover-up. He escapes en route to his execution and seeks refuge in the Ecliptic Express, a stranded train, where he meets Rebecca Chambers. The two form an alliance in order to survive, using their talents to discover the Umbrella Corporation's secrets. Both characters are monitored by the Queen Leech-James Marcus hybrid, who sends various creatures to subdue them. After revealing the details of his demise, the hybrid Marcus fully mutates into the Queen Leech. In the final battle sequence, Billy and Rebecca destroy the Queen Leech by exploiting its vulnerability to sunlight. Rebecca allows Billy to escape, believing his claims that he is innocent and telling the authorities that he subsequently perished in the Arklay Mountains after their encounter. Billy also appears in  The Umbrella Chronicles.

Jake Muller

 * Voiced by (English): Troy Baker (RE6)
 * Voiced by (Japanese): Daisuke Namikawa (RE6)
 * Motion capture: Troy Baker, Daniel Southworth (stunt double)

Jake Muller appears as one of the four main protagonists in Resident Evil 6. He is the illegitimate son of the Albert Wesker; it is believed that Wesker was not aware of his son's existence, as Jake's mother left shortly after being impregnated by him. Jake later works as a freelance mercenary in order to support his mother, whom dies of an unknown chronic disease shortly after Jake receives money for her treatment. Jake was caught up in an act of bioterrorism while operating in anti-government operations in the fictional Eastern European republic of Edonia. His mercenary comrades are infected with the C-virus, but Jake's specialized blood resists the infection. Soon after, he meets US government agent Sherry Birkin – whose father, William Birkin, was coincidentally Albert's research partner. Sherry and Jake take part in the subsequent battle between the Bioterrorism Security Assessment Alliance and the mutated mercenaries.

Ethan Winters
The main character of Resident Evil 7: Biohazard and Resident Evil Village, Ethan is introduced as a civilian who travels to the Bakers' dilapidated family estate in Dulvey, Louisiana in search of his missing wife Mia, and is later relocated to an undisclosed location in Eastern Europe following the events of Resident Evil 7.

Rose Winters

 * Voiced by (English): Jeannie Tirado (Teenager)
 * Voiced by (Japanese): Yurianne Eve (Teenager)
 * Face model: Linde Baars

Rosemary "Rose" Winters is the daughter of Ethan Winters and his wife Mia. In Resident Evil Village, she is kidnapped by Mother Miranda, who intends to use her latent powers inherited from her parents to resurrect her own daughter, Eva. After Chris Redfield rescued the real Mia, whom Miranda kidnapped and impersonated, Rosemary is revealed to be a half-Mold through her father's exact nature as a sentient Mold. With the help of Chris, Ethan rescues Rosemary from Miranda but at the cost of his own life.

Rose also serves as the playable character in Village's DLC chapter Shadows of Rose, set sixteen years after the main events of the game. Files reveal that Rose grew up an outcast due to her nature and abilities that manifested throughout her childhood. Rose has also grown distant from her mother and trained by Chris, even being scouted for Hound Wolf Squad. After learning that she can remove her powers, she enters the realm of the Megamycete to recover a crystal capable of doing so. Navigating the realm, she faces both its twisted creations and remnants of those connected to the Megamycete, such as Eveline and a replica of the Duke. Rose also receives assistance from an entity calling himself Michael, though she eventually learns it to be the remnant of her father Ethan. After acquiring the crystal, Rose learns that it was actually a trap set by the remnant of Miranda, who lured her into the realm in another attempt to resurrect Eva through her. With help from Ethan, Rose is able to regain her powers and kills Miranda for good. Having been able to meet her father, Rose leaves the realm content with her nature. In the epilogue of both the game and DLC chapter, it is revealed Rose has joined Hound Wolf Squad and uses her abilities to fight BOWs.

Umbrella Corporation
The Umbrella Corporation is an American-based international pharmaceutical company in the Resident Evil universe. Founded in 1968 by prominent British royal descendants Oswell E. Spencer and Edward Ashford, along with Dr. James Marcus, it is portrayed in the series as a major international player in pharmaceutical goods and medical supplies, along with more clandestine operations utilizing genetic engineering. Their legitimate status is only a front for their secret research of "bio-organic weapons" (B.O.W.s), developed through the use of a unique mutagenic virus discovered by the company founders known as the Progenitor Virus.

Oswell E. Spencer

 * Voiced by: Adam D. Clark (RE5), Time Winters (REmake 3)
 * Voiced by (Japanese): Issei Futamata (REmake 3)
 * Motion capture: Adam D. Clark (RE5)

Oswell E. Spencer (オズウェル・E・スペンサー) is the owner and co-founder of the Umbrella Corporation, a pharmaceutical drug company that secretly manufactures bio-organic weapons. With limited funding to exploit the flower and its virus, Spencer designs a seemingly benevolent front organization known as Umbrella Pharmaceuticals to accrue revenue so that his machinations on the virus may continue. His colleagues, James Marcus and Edward Ashford, join his company. Through a series of betrayals and espionage, Spencer quickly gains control of the company and its research, and sends subordinates to assassinate Marcus and Ashford. Spencer conducts some of his company's research in the Arklay Research Facility, located in the Arklay Mountains. He hires George Trevor, a famous architect, to construct a mansion to conceal the facility, however, with Trevor knowing the secret to the mansion he had just built, Spencer has the architect targeted for assassination and proceeds to abduct Trevor's wife and daughter, having them become test subjects for virus research and development. Trevor's daughter Lisa would become a promising specimen for new fields of bio-exploitation, experiencing much torment and mutilations in the process. Spencer's plans progress smoothly until Marcus returns from the dead through the Queen Leech as absorbing his genetic memory, motivated by revenge to destroy one of Spencer's luxury trains and cause a viral outbreak in the Arklay Research Facility. The outbreak spreads throughout the region, sparking the events of Resident Evil Zero and the original Resident Evil. The virus subsequently spreads to Raccoon City during the events of Resident Evil 2 and Resident Evil 3: Nemesis, prompting the U.S. government to attempt to contain the outbreak by ordering the destruction of the city.

After the city's destruction, Spencer attempts to disguise the incident as a government conspiracy by hiring top lawyers and false witnesses. His actions prolong the legal proceedings and allow the Umbrella Corporation to stay afloat for five more years. Ultimately, Albert Wesker betrays Spencer by handing over secret documents to the U.S. government while providing personal testimony in court. Spencer becomes a wanted man and goes into hiding at his mansion in Europe. Wesker kills Spencer before Chris Redfield and Jill Valentine can arrest him.

Alexia Ashford

 * Voiced by: Leila Johnson (Code: Veronica), Karen Strassman (The Darkside Chronicles)
 * Played by: Heloise Catherine (Welcome to Raccoon City)

Alexia Ashford (アレクシア・アシュフォード) is the primary antagonist of Resident Evil – Code: Veronica. Along with her twin brother Alfred, she is the product of a cloning experiment by her father to recreate the legendary ancestor Veronica Ashford. Alexia inherits her legendary intelligence and beauty, though became obsessed with becoming an unstoppable world dictator. After developing the T-Veronica virus, Alexia infected herself with the T-Veronica Virus and goes into cryostasis for several years, allowing her to gain control of the virus and retain her personality. She is awoken by a dying Alfred during the events of Code: Veronica. In revenge for this, she sends one of her tentacle monsters to capture Claire and Steve, experimenting on the latter and turning him into a large monster. She is confronted by Albert Wesker towards the end of the game and mutates into her first form, driving him off but is then defeated by Claire's brother Chris. Alexia revives and appears at the very end of the game as the final boss, mutating into another two forms before Redfield kills her for good with the Linear Launcher. Alexia also appears in The Darkside Chronicles as part of a reimagined scenario for Code: Veronica.

In the reboot film Resident Evil: Welcome to Raccoon City (2021), a young Alexia is played by Heloise Catherine.

Alfred Ashford

 * Voiced by: Peter Oldring (Code: Veronica), Richard Cansino (The Darkside Chronicles)
 * Played by: Sophia Ann Pead Gavin (Welcome to Raccoon City)

Alfred Ashford is an antagonist of Resident Evil – Code: Veronica. Created as an experiment by his legal father, Alfred is brought up idolizing his sister, who had inherited many of the ancestor's positive traits. After discovering their origins, Alfred infects Alexander with the T-Veronica virus and is left the patriarch of the Ashford family whilst Alexia goes into cryostasis. He uses his connections with Umbrella to take control of Rockford Island, transforming it into a prison facility and training camp. Unknown to all, Alfred develops split personality based on Alexia, go as far as acting and dressing like his sister. Alfred serves as Claire and Steve's main adversary throughout Code: Veronica, following them throughout the Rockford Island facility and setting up traps for them. Eventually mortally injured during a confrontation at the Antarctic facility, Alfred restores Alexia before dying in her arms. His body is later discovered stuffed into Alexia's cryogenic tube by Chris, who obtains his family jewel to unlock part of the facility. Alfred also appears in Code: Veronica's retelling in The Darkside Chronicles, though he is killed by Alexia for "waking her too late" rather than succumbing to his injuries.

In the reboot film Resident Evil: Welcome to Raccoon City (2021), a young Alfred is played by Sophia Ann Pead Gavin.

Carlos Oliveira

 * Voiced by (English): Vince Corazza (RE3), Scott McNeil (Under the Skin), Gideon Emery (Operation Raccoon City), Jeff Schine (REmake 3) Drake Mefestta (Dead by Daylight)
 * Voiced by (Japanese): Shoto Kashii (Under the Skin), Masaki Terasoma (Apocalypse, Extinction, Retribution), Masashi Ebara (Extinction, Retribution, TV dub), Hiroki Yasumoto (Operation Raccoon City, REmake 3)
 * Face model: Benson Mokhtar (REmake 3)
 * Motion capture performance by: Jeff Schine (REmake 3)
 * Played by: Oded Fehr (Apocalypse, Extinction, Retribution)

Carlos Oliveira (カルロス・オリヴェイラ), the second main character of Resident Evil 3, is a mercenary and a former member of a South American communist guerrilla group. After the government forces wiped out his organization, Carlos was scouted out by the Umbrella Corporation to join Umbrella's UBCS. He joined the force and was assigned to Delta Platoon, Company A (serving alongside Nicholai Ginovaef and Mikhail Victor), which was in charge of heavy firearms and weapons maintenance. Despite his violent background, he is warm-hearted and known for joking around. In Resident Evil 3: Nemesis, Carlos assists Jill Valentine throughout the game as the two of them attempt to escape Raccoon City. After she becomes infected by the T-virus after a battle with the Nemesis, he recovers a vaccine to treat her and successfully escapes the city with Jill. In the remake, Carlos' role as a playable character is expanded upon, including a brief excursion to the Raccoon City Police Department. He also appears as a playable character in The Umbrella Chronicles, where the events of Resident Evil 3 are revisited in the "Raccoon's Destruction" scenario.

In the Resident Evil movie franchise, Carlos' surname is spelled "Olivera". His character plays a similar role to his video game counterpart as a disgruntled Umbrella mercenary. In Resident Evil: Apocalypse, he is briefly infected with the T-virus, but Alice finds a sample of the antivirus in time to cure him. In the third film, he and Alice parted company five years ago when Alice sought to protect her allies from the Umbrella satellites tracking her, but they meet again when he is travelling with a convoy led by Claire Redfield. When Carlos is bitten during an attempt to capture Alice, he volunteers to mount a suicide run on the Umbrella complex tracking Alice after it takes a series of prisoners from the convoy, reasoning that there is no time to get a sample of the antivirus before the infection becomes permanent, taking a fuel tanker into the mass of zombies surrounding the base and then setting off a series of bombs, taking out a sizeable number of zombies and breaching the complex defenses.

Mikhail Victor

 * Voiced by (English): Benedict Campbell (RE3), William Hope (REmake 3)
 * Voiced by (Japanese): Naoki Tamanoi (REmake 3)
 * Motion capture performance by: William Hope (REmake 3)

Mikhail Victor (ミハイル・ヴィクトール) is the leader of the UBCS Delta platoon that both Nicholai and Carlos are members of. According to his backstory, Mikhail is from Saint Petersburg, Russia, and had originally served in the army before joining a rebel group. Mikhail was eventually arrested by Russian government forces and convicted for acts of terrorism. He was then coerced into leading the UBCS in exchange for his men's freedom. In the game, he appears already wounded, choosing to sacrifice his own life to save Jill and Carlos as he dies after being blown apart by his own grenade in a failed attempt to destroy the Nemesis. In an early draft of the story, Mikhail was originally scripted to be Nicholai's older brother, hence their common nationality and close ages (his original name was Mikhail Ginovaef). Mikhail also appears in the game's remake, maintaining the same role as the original game, in addition of knowing Jill's identity as a member of a defunct S.T.A.R.S. team, and suspicious about Nicholai's true motive. He is the only one of the main UBCS operatives not to appear in the film Resident Evil: Apocalypse, where he is replaced by an original character named Yuri Loginova.

Nicholai Ginovaef

 * Voiced by (English): Roger Honeywell (RE3), Rick D. Wasserman (Operation Raccoon City), Neil Newbon (REmake 3, Resistance)
 * Voiced by (Japanese): Rikiya Koyama (Apocalypse, TV dub) Kenta Miyake (Operation Raccoon City, REmake 3)
 * Motion-capture performance by: Neil Newbon (REmake 3)
 * Played by: Zack Ward (Apocalypse)

Nicholai Ginovaef (ニコライ・ジノビエフ) is a member of the UBCS Delta platoon, Company B. According to his backstory, Nicholai is from Moscow and served in the Russian Spetsnaz before joining the UBCS. He also has an unspoken rivalry with HUNK. In Resident Evil 3: Nemesis, Nikolai is one of the few surviving operatives from the Delta platoon, along with Carlos and Mikhail. He disappears after an event in the first half of the game and is presumed dead until another encounter with him. It is revealed that Nikolai is in fact one of the Supervisors UBCS operatives, assigned to watch and gather combat data as their comrades fight against Umbrella's bio-weapons. Nicholai's fate depends on decisions made by the player, resulting in either his escape or death, either at the hand of Jill or the Nemesis. In the Resident Evil 3 remake, Nicholai is changed to a mole implanted within the UBCS for an unnamed organization. Hired to mitigate the company's efforts to contain the T-virus outbreak, he murders research staff and tries to gain and destroy a virus vaccine. In the final confrontation with Jill and Carlos, he is injured and left behind in Raccoon City. The English localization of Resident Evil Survivor features a document supposedly authored by Nicholai after the events of Nemesis. The file is different in the original Japanese version and the Chinese localization of the PC port. The third entry of the document (the portion dated after the events of Nemesis) was actually authored by the "Umbrella B.O.W. Development Staff", rather than Nikolai. Nicholai also appears in Resident Evil Outbreak in the final scenario "Decisions, Decisions", which depicts the character conducting another mission occurring during the same time period as the second half of Resident Evil 3. He is mentioned in The Umbrella Chronicles, where he is referred to by the codename "Silver Fox". Nicholai's role in Resident Evil: Operation Raccoon City was stopping Wolfpack from completing their mission objective.

The character was adapted for the film Resident Evil: Apocalypse, although the film features a more heroic depiction of Nicholai, which differs from the game's original antagonistic portrayal of the character. In the film's novelization, he was renamed Nicholai Sokolov. Nicholai is ultimately torn to shreds by zombie dogs while holding them off so Alice and Jill can escape.

HUNK

 * Voiced by (English): Keith Silverstein (The Umbrella Chronicles, The Darkside Chronicles, Operation Raccoon City, Revelations, REmake 2)
 * Voiced by (Japanese): Masaki Terasoma (Operation Raccoon City, Revelations, REmake 2)

HUNK (ハンク) is an enigmatic special forces agent of the Umbrella Security Service unit in Resident Evil 2. His notoriety for being the sole survivor of multiple operations earned him the moniker 'Grim Reaper'. HUNK initially appears in Resident Evil 2, where he is playable in a secret minigame titled "4th Survivor". This short scenario entails HUNK's journey to escape Raccoon City, beginning with his awakening in the sewers and eventually leading to his extraction from the city. He is the only member of his unit to survive the attack of the mutated William Birkin that takes place shortly after he secured a sample of the G-virus for Umbrella. He reappears in The Umbrella Chronicles, in a remake of the "4th Survivor" scenario where the player must reach the helipad for extraction from Raccoon City, and during the "Memories of a Lost City" scenario in Resident Evil: The Darkside Chronicles. HUNK is playable in the "Mercenaries" minigame in Resident Evil 4, but has no relation to the story. HUNK appears as a side character in Resident Evil: Operation Raccoon City, where he works with other Umbrella Security Service operatives to recover a sample of the G-virus prior to the events of Resident Evil 2. He is also a playable character in Resident Evil: The Mercenaries 3D, Resident Evil: Revelations, and Resident Evil: Revelations 2.

Alex Wesker

 * Voiced by (English): Mary Elizabeth McGlynn (Revelations 2, REmake 3)
 * Voiced by (Japanese): Rica Fukami (Revelations 2, REmake 3)
 * Motion capture: Elaine Hendrix (Revelations 2)
 * Face Model: Elaine Hendrix (Revelations 2)

The main antagonist of Resident Evil: Revelations 2, an Umbrella researcher who quotes Franz Kafka and developed the T-Phobos virus, which causes those infected to mutate when overcome with fear. Alex is the only other surviving participant of the Wesker project besides her “brother” Albert Wesker despite lacking Albert's heightened abilities. Alex uses her position in Umbrella to establish a facility on the impoverished Sejm Island, kickstarting an economic recovery while exploiting the residents to be her test subjects for T-Phobos Project that Spencer assigned her as a means for him to cheat death. But Alex is spurred by her failing health to instead develop a method to transplant a digital copy of her mind into a host body able to resist fear. Hastening her work after learning of Spencer and Albert's deaths, Alex exploits Neil Fisher with the Uroboros virus she was refining to provide her with candidates from TerraSave, with only Claire Redfield and Moira Burton the sole survivors of her experiments.

Alex also captures Natalia Korda as her ideal host, disposing of Fisher before proceeding with her experiment before committing suicide with the expectation to awaken as Natalia within six months. But she is instead mutated by the T-Phobos at the last second from fearing her own demise, suffering an existential crisis with the maddened resolve to kill Natalia before her copy could manifest by releasing the Uroboros virus on the island as Barry arrived. After infecting herself with the Uroboros, Alex is killed during the BSAA's assault on the island. Regardless of Alex's death, her copy starts manifesting as depicted in the bonus episode "Little Miss" and the game's epilogue.

Annette Birkin

 * Voiced by (English): Jennifer Dale (RE2), Deborah Sale Butler (The Darkside Chronicles), Karen Strassman (REmake 2, REmake 3)
 * Voiced by (Japanese): Marika Hayashi (REmake 2, REmake 3)
 * Motion capture: Karen Strassman (REmake 2)
 * Played by: Janet Porter (Welcome to Raccoon City)

Annette Birkin (アネット・バーキン) is a supporting character in Resident Evil 2. She is involved in Bio Organic Weapon research at Umbrella, working with her husband William to create the G-virus. During the Raccoon City outbreak, Annette works to stop Umbrella's experiments from spreading further into the city. She leaves their daughter Sherry at the Raccoon Police Department with a pendant containing the virus, hoping Irons can protect her. During the game's events, Annette helps Claire cure Sherry's G-virus infection and reveals Ada's true motives to Leon. She is fatally injured, forcing them to leave her behind. Annette appears in the game's remake, maintaining the same role as in the original game, and its retelling in The Darkside Chronicles.

In the reboot film Resident Evil: Welcome to Raccoon City (2021), Annette is played by Janet Porter.

James Marcus

 * Voiced by (English): Ian Downie (RE0)
 * Voiced by (Japanese): Hiroshi Ito (RE0)
 * Played by: Mark Simpson (The Final Chapter)

James Marcus (ジェームス・マーカス) is the main antagonist of Resident Evil Zero. Years before the events of the first Resident Evil, he was one of the top virologist researchers of the Umbrella Corporation and a head of its personnel training facility, personally appointed by Oswell E. Spencer to work with the Progenitor virus. In this capacity, Marcus played an integral role in developing the T-virus (Tyrant virus), and the Tyrant and Nemesis programs, also conducting extensive research on leeches that led to the development of the G-virus, up until his death in 1988. Spencer betrayed him by sending Marcus' direct subordinates, Albert Wesker and William Birkin, to murder him and steal his research. They dumped his body away along with the Queen Leech that Marcus created, the creature consuming his body and ended up absorbing his genetic memory as consequence. This resulted in the Queen Leech believing itself to be Marcus reborn. Serving as the antagonist of Resident Evil Zero, The Queen Leech avenges the real Marcus by triggering the events of the first Resident Evil game by causing a T-virus outbreak in the Arklay Mansion before being destroyed by Rebecca Chambers and Billy Coen. Marcus also appears in The Umbrella Chronicles.

In the film Resident Evil: The Final Chapter (2016), James is played by Mark Simpson. In the film, it is revealed that Alice is a clone of James's daughter, Alicia Marcus. In the Netflix's live-action series (2022), set in its own universe but featuring the game series storyline as its backstory, James Marcus has a daughter named Evelyn, played by Paola Núñez, who inherited control of Umbrella.

William Birkin

 * Voiced by (English): Diego Matamoros (RE2), T.J. Rotolo (The Umbrella Chronicles, The Darkside Chronicles, Operation Raccoon City, REmake 2), Misha Standjofski (Dead by Daylight)
 * Voiced by (Japanese): Toshihiko Seki (Operation Raccoon City, 0, REmake 2)
 * Motion capture: T.J. Rotolo (REmake 2)
 * Played by: Jason Isaacs (RE), Neal McDonough (Welcome to Raccoon City)

William Birkin (ウィリアム・バーキン) is one of the main antagonists in the Resident Evil series, specifically Resident Evil 2. After completing his G-virus project (Golgotha virus), he is mortally wounded by agents of the Umbrella Special Forces and his work is stolen. Left for dead, he injects himself with the G-virus, thus turning himself into a monster known as "G". He then kills his attackers, causing a T-virus vial to be leaked into the city's drainage system, resulting in the zombie outbreak in Raccoon City. During the course of the game, he encounters the main characters, Claire Redfield and Leon S. Kennedy, as he undergoes gradual mutation and begins losing any resemblance of his original human form. He is eventually defeated by Claire and Leon, with the help of his daughter Sherry. Birkin is mentioned in Wesker's Report as the scientist who helped Wesker fake his death and is retroactively mentioned in the GameCube remake of the first Resident Evil. He also makes an appearance in Resident Evil Zero, where he assists Wesker from behind the scenes, and also appears in a cutscene in The Umbrella Chronicles along with Albert Wesker.

In the first Resident Evil film, Birkin makes an uncredited cameo appearance portrayed by Jason Isaacs as the head of the Nemesis project, who was also the film's narrator. According to an audio commentary by Paul W. S. Anderson, Isaacs was planned to reprise this role in the sequel Resident Evil: Apocalypse, but left the project for undisclosed reasons, so an original character named Dr. Alexander Isaacs (played by Iain Glen) was created to fulfill Birkin's role in the sequel.

In the reboot film Resident Evil: Welcome to Raccoon City (2021), Birkin is played by Neal McDonough, appearing as the main antagonist of the film.

Piers Nivans

 * Voiced by (English): Chris Emerson (RE6)
 * Voiced by (Japanese): Shuhei Sakaguchi (RE6)
 * Face Model: Adam Crosman (RE6)
 * Portrayed by: Wataru Kuriyama (stage play)

Piers Nivans is a member of the North American Branch of the BSAA in Resident Evil 6. He is a talented marksman, who served under Chris Redfield during the Edonian Civil War in 2012. On one of their missions, Carla Radames infects their comrades with the C-virus and turns them into mutants. Chris is knocked unconscious in the ensuing battle but is rescued by Piers. Chris becomes disillusioned and disappears after recovering. Piers tracks down Chris and successfully convinces him to rejoin the BSAA to avenge his dead comrades. They are deployed to Lanshiang, China and tasked to stop a bio-terrorism attack. The duo are eventually led to an underwater laboratory that is being used to create powerful bio-organic weapons. Piers is severely injured during their final battle with the B.O.W., Haos, and injects himself with the C-virus to continue fighting. After he and Chris manage to defeat the Haos, they then attempt to escape the laboratory during its self-destruction sequence, but after realizing that he is beginning to succumb to the C-virus, Piers seals Chris inside an escape pod in order to ensure his survival, while he stays behind during the laboratory's destruction to prevent himself from mutating any further, sacrificing himself in the process. Right before his death, Piers manages to save Chris from the still-alive Haos by killing it as it attempts to destroy the escape pod Chris is in. Chris honors Piers's memory by remaining with the BSAA (when before, Chris thought of retiring and leaving Piers in charge). Piers is mentioned by name during the epilogue in Resident Evil: Revelations 2, as he is in China with Chris.

Brad Vickers

 * Voiced by (English): Evan Sabba (RE3), Adam Paul (REmake), Darren O'Hare (REmake 3)
 * Motion Capture Performance by: Neil Newbon (REmake 3)
 * Voiced by (Japanese): Wataru Takagi (REmake 3)
 * Played by: Nathan Dales (Welcome to Raccoon City)

Brad Vickers (ブラッド・ヴィッカーズ) is a STARS helicopter pilot and Alpha team's computer and information expert, nicknamed "Chickenheart". He leaves his teammates stranded in the forest during the opening of the first Resident Evil after panicking, but returns at the end of the game to save the survivors (Jill, Chris, Barry, and Rebecca). In Resident Evil 3, despite trying to avoid any further involvement in the events surrounding Umbrella, Brad is targeted by Nemesis and eventually killed. He can be seen as a zombie in front of the police department in Resident Evil 2 if the player meets certain goals. Brad's fate was altered in the Resident Evil 3 remake where he is infected by a zombie bite and reanimates before being put down by Carlos.

In the reboot film Resident Evil: Welcome to Raccoon City (2021), Brad Vickers is played by Nathan Dales.

Richard Aiken

 * Voiced by (English): Joe Whyte (REmake)
 * Voiced by (Japanese): Yūji Ueda (REmake HD Remaster)
 * Played by: Chad Rook (Welcome to Raccoon City)

Richard Aiken (リチャード・エイケン) is the STARS' radio communications specialist and one of the Bravo Team members involved in the Spencer Mansion Incident. In the original Resident Evil game, he is found on the east wing of the Mansion's second floor, severely wounded and poisoned by a giant snake. After a brief detour to collect antivenom, Richard dies, either after imparting information and a radio (if the player returns quickly), or prior to their return. In the remake version, whilst playing as Jill, Richard will accompany the player into the fight with Yawn, sacrificing himself to push her away from a lethal attack, and being ingested by the snake. Whilst playing as Chris, Richard will be killed during the encounter with the shark-based Neptune monster. In the novel The Umbrella Conspiracy, Richard is found by Chris and Rebecca, already dead from the poison. In Resident Evil: The Umbrella Chronicles, Richard is a companion of Rebecca. He is one of the playable characters in the multiplayer mode of Resident Evil: Deadly Silence.

In the reboot film Resident Evil: Welcome to Raccoon City (2021), Aiken is played by Chad Rook.

Brian Irons

 * Voiced by (English): Gary Krawford (RE2), JB Blanc (The Darkside Chronicles), Sid Carton (REmake 2)
 * Voiced by (Japanese): Akio Hirose (REmake2)
 * Motion capture: Sid Carton (REmake 2)
 * Played by: Donal Logue (Welcome to Raccoon City)

Brian Irons is the Police Chief of the RPD. He is secretly bribed by Umbrella to cover up the T-virus outbreak in the Arklay laboratories and their experiments with the G-virus. During the Raccoon City outbreak, Irons goes insane and begins killing people in the department building indiscriminately, including Mayor Warren's daughter Katherine. Irons is encountered several times by Claire Redfield, who gradually learns of his alliance with Birkin and Umbrella. He is eventually killed by a mutated William Birkin. In the game's remake, Irons kidnaps Sherry Birkin and tries to use her pendant to access the NEST facility. It is also revealed that he is also the director of an orphanage used to supply Umbrella with human test subjects, where he holds her until he can retrieve her pendant from Claire. Irons chases Sherry as she attempts to escape, but is eventually attacked and implanted with a G-embryo. He dies when the creature erupts from his body just as Claire arrives to confront him. Irons also appears in The Darkside Chronicles, though his role is greatly downplayed to a brief confrontation with Leon and Claire.

In the reboot film Resident Evil: Welcome to Raccoon City (2021), Irons is played by Donal Logue and is considered more heroic than his game counterpart.

Elliot Edward

 * Voiced by (Japanese): Kenji Takahashi (REmake 2)

Elliot Edward is an RPD officer and minor character in Resident Evil 2. He appears in the opening minutes of Scenario B trying to reach an evacuation helicopter. However, he is attacked and killed by zombies, during which he causes the helicopter to crash by accidentally shooting the pilot and blocks off part of the RPD. In the remake, Elliot works with other officers in an attempt to escape the overrun RPD. Eventually discovering a way out, he is ripped apart by creatures as he attempts to get to the player's character, though is able to give them the information about a secret passage. His corpse later transforms into a zombie.

Marvin Branagh

 * Voiced by (English): Lex Lang (The Darkside Chronicles), Christopher Watson (REmake 2. REmake 3)
 * Voiced by (Japanese): Fuminori Komatsu (REmake 2, REmake 3)
 * Motion capture: Christopher Watson (REmake 2, REmake 3)

Marvin Branagh is a lieutenant in the RPD. In the original Resident Evil 2, he is discovered suffering from a serious injury in Scenario A by either Leon or Claire, and informs them of the Mansion Incident. Giving them his keycard to unlock areas of the police station, he forces them to leave him behind and locks the door behind them. Marvin later transforms into a zombie and attacks the player. In the Resident Evil 2 remake, he is more proactive in helping the protagonists escape the RPD and helps them unlock the passage before also becoming a zombie when the player returns to the RPD. Marvin also appears briefly in both versions of Resident Evil 3, the remake showing that he was infected by a zombified Brad Vickers. Marvin also appears in Resident Evil Outbreak: File 2 and The Darkside Chronicles.

Ingrid Hunnigan

 * Voiced by (English): Salli Saffioti (RE4, Degeneration, Damnation, RE6, Death Island), Raylene Harewood (REmake 4)
 * Voiced by (Japanese): Yū Sugimoto (Degeneration, Damnation, RE6, REmake 4)
 * Motion Capture performance: Jolene Andersen (Damnation)

Ingrid Hunnigan serves as Leon S. Kennedy's Case Officer. As an F.O.S. agent (Field Operations Support) Hunnigan provides Leon with tactical information relevant to his current situation. She assisted him during his missions to rescue Ashley Graham in Resident Evil 4 and to stop Neo-Umbrella in Resident Evil 6. She also makes brief appearances in Resident Evil: Degeneration and Resident Evil: Damnation, plus Resident Evil: Death Island.

Sherry Birkin

 * Voiced by (English): Lisa Yamanaka (RE2), Laura Bailey (The Darkside Chronicles), Eden Riegel (Operation Raccoon City, RE6), Eliza Pryor (REmake 2)
 * Voiced by (Japanese): Mayumi Iizuka (Resident Evil 2 drama cd, child), Hisako Kanemoto (Operation Raccoon City, child), Maaya Sakamoto (RE6, adult), Rio Sasaki (REmake 2, child)
 * Motion Capture performance: Sara Fletcher (RE6), Eliza Pryor (REmake 2)
 * Facial Model: Sara Fletcher (RE6)
 * Played by: Holly de Barros (Welcome to Raccoon City)

Sherry Birkin (シェリー・バーキン) is the daughter of William and Annette Birkin. She first appears in Resident Evil 2, running away and hiding in Raccoon City during the outbreak. She manages to find Leon and Claire, who protect her while trying to escape the city. Sherry is a playable character in some parts of the game but she is completely unarmed and can only avoid the monsters. In the remake, she is abducted and held hostage by Brian Irons before being rescued by Claire. Her father has been transformed into a monstrous creature by the G-virus and infects her, but Claire gives Sherry an anti-virus, which prevents her from mutating. Sherry assists Leon and Claire in boarding a secret underground train, and successfully escapes Raccoon City before it is destroyed. Sherry also appears in Resident Evil: The Darkside Chronicles in chapters that recapitulate the events of Resident Evil 2. She returns as an adult in Resident Evil 6 as a government agent escorting Jake Muller and seems to have acquired great healing abilities from the remnants of the G-virus in her body. During the course of the game, she helps Jake deal with the fact that Albert Wesker is his father. She also learns from Leon S. Kennedy that her superior, Derek C. Simmons, is the man responsible for the U.S. President's death. She and Jake subsequently ally with Leon, Chris Redfield and their partners in thwarting Carla Radames' plans.

In the reboot film Resident Evil: Welcome to Raccoon City (2021), Sherry is played by Holly de Barros.

Derek C. Simmons

 * Voiced by (English): David Lodge (RE6)
 * Voiced by (Japanese): Takayuki Sugō (RE6)

Derek Clifford Simmons is the primary antagonist of Leon's campaign in Resident Evil 6. Simmons is the National Security Advisor and a close friend to President Adam Benford. He is the leader of a secret organization known as "The Family" who his ancestor founded, using its vast political influence to maintain world order. He hired Ada Wong to acquire the G-Virus while overseeing the missile strike on Raccoon City, taking her resignation hard as he became Sherry Birkin's legal guardian. He secretly used a sample of her G-Virus-enhanced blood to synthesize the C-Virus, using a variant of it to turn his top scientist Carla Radames into a clone of Ada Wong he later deploys to capture Jake Muller. Simmons then orchestrates the assassination of President Benford in fear that his act of declassifying the Raccoon City incident would jeopardize national security, coercing Helena into infecting the president with the C-virus while causing a viral outbreak in Tall Oaks to cover his tracks with Helena and Leon as his scapegoats. But Simmons was undone by a revenge-driven Carla Radames using the C-Virus, forcing him to travel to China where he gets infected with an Enhanced version of the C-virus and is forsaken by the Family. This results in Simmons being able to mutate into a variety of monstrous forms that include a giant insect-like form from absorbing C-Virus infected zombies, before he was ultimately killed.

Helena Harper

 * Voiced by (English): Laura Bailey (RE6)
 * Voiced by (Japanese): Mayumi Sako (RE6)
 * Facial model by: Natasha Alam

Helena Harper is an agent in the Secret Security Service (USSS) and the personal bodyguard of U.S. President Adam Benford. Harper is a former CIA operative, who receives a second-chance with the USSS after facing two suspensions for using excessive force to defend her family. Derek Simmons blackmails Harper into helping his organization cause a C-virus outbreak in Tall Oaks by kidnapping Helena's sister, Deborah. Benford is infected in the ensuing viral outbreak and becomes a zombie, prompting Kennedy to reluctantly shoot him in the head. Harper and Kennedy work together to locate Deborah before learning Simmons has mutated her into a BOW. Helena is forced to kill her sister, and reveals she worked with Simmons to cause the C-virus outbreak under duress. She eventually confronts and kills Simmons in Lanshiang, China. Harper is cleared of any wrongdoing after the government investigates Simmons’ background.

Moira Burton

 * Voiced by (English): Marcella Lentz-Pope (Revelations 2)
 * Voiced by (Japanese): Ayumi Fujimura (Revelations 2)

Moira Burton (モイラ・バートン Moira Bāton) is the eldest daughter of STARS veteran, Barry Burton. In Resident Evil: Revelations 2, Moira and her TerraSave co-workers including Claire Redfield are captured and taken to an abandoned prison facility supervised by Alex Wesker. Moira is a secondary character in Claire's portion of the game. She refuses to use firearms after accidentally wounding her younger sister with a handgun as a child. Instead, Moira uses tools, such as crowbars, to break open boxes and to attack enemies. She is estranged from her father. Eventually while fighting a mutated Neil Fisher, who betrayed the TerraSave group, Moira overcomes her fear of using guns in order to save Claire if the player selects this option, which is canon. Moira is separated from Claire and saved by Evgeny, a sick Russian man who later chooses death once his daughter is dead. Moira then returns to save her father and friends from Alex Wesker, who is now fully mutated.

Osmund Saddler

 * Voiced by (English): Michael Gough (RE4), Christopher Jane (REmake 4)
 * Voiced by (Japanese): Hōchū Ōtsuka (REmake 4)
 * Motion capture: Kenji Hata (RE4)

Osmund Saddler (オズムンド・サドラー) is the main antagonist of Resident Evil 4. He is the leader of Los Illuminados, the cult responsible for Ashley Graham's kidnapping. Saddler plans on infecting Graham with a sample of Las Plagas, in hope that she will return home and infect higher-ranking members of the U.S. government. Saddler then attempts to control them and seize control of the country, and then the world. He uses samples of Las Plagas to infect and control villagers and even a local castellan Ramon Salazar to perform his bidding. However, his plans are foiled by the combined efforts of Kennedy, Wong and Luis Sera. Kennedy, with the assistance of Wong, kills Saddler near the game's conclusion, and destroys his research and production complex. Saddler also appears in the 2023 remake of Resident Evil 4, largely maintaining his original role. However, unlike the original game, Saddler does not make a physical appearance until Kennedy reaches the island in the third act of the game. The remake also expands slightly on his backstory, revealing he was a descendant of the first followers of Los Illuminados who ended up exiled to the island, rather than an outsider who took control of the cult to put his plan in motion.

Ramon Salazar

 * Voiced by (English): Rene Mujica (RE4), Marcio Moreno (REmake 4)
 * Voiced by (Japanese): Chō (REmake 4)
 * Motion capture: Tsurugi-Dan (RE4)

Ramon Salazar (ラモン・サラザール) is an antagonist in Resident Evil 4. He is the castellan of the castle affiliated with Los Iluminados. He comes from a noble family, who were responsible for sealing Las Plagas beneath the castle's grounds. Years later, Saddler, a cultist who worships Las Plagas, persuaded Salazar to unearth the parasites, causing them to spread across the local area. Salazar controls the Ganados and orders them to kill Kennedy and apprehend Ashley Graham. He merges with his second bodyguard in a Queen Plaga to become a gigantic abomination in a desperate attempt to defeat Kennedy, but perishes during the ensuing fight. Salazar also appears in the 2023 remake, maintaining much of his role from the original game.

Bitores Mendez

 * Voiced by (English): Jesse Corti (RE4), Jon Bryant (REmake 4)
 * Voiced by (Japanese): Takeshi Oba (REmake 4)
 * Motion capture: Kenji Hata (RE4)

Bitorez Mendez is a minor antagonist in Resident Evil 4. He is the chief of the village taken over by the Los Illuminados cult and is given a Dominant Species of the Plaga Parasite, allowing him to command others infected with Las Plagas and granting him incredible strength. Mendez is confronted numerous times in the game's early chapters and confronts Leon Kennedy on multiple occasion. In their last confrontation, Mendez is forced to mutate after being doused in gasoline and set on fire, though is eventually defeated by Leon. Mendez also appears in the 2023 remake of the game, maintaining his role from the original game. Resident Evil Archives II states that Mendez used to be a Catholic priest before being converted to the Los Illuminados cult.

Jessica Sherawat

 * Voiced by (Japanese): Nana Mizuki

Jessica Sherawat is an operative of TRICELL who appeared in Resident Evil Revelations, first infiltrated the FBC during the Terragrigia Panic, and later transferred to the BSAA a year later during their investigation of Il Veltro terrorists to acquire a sample of the T-Abyss TRICELL made for Morgan Lansdale. She ultimately succeeds with the assistance of Raymond Vester keeping both groups unaware of their actual goals.

Jack Krauser

 * Voiced by (English): Jim Ward (RE4, The Darkside Chronicles , The Mercenaries 3D), Mike Kovac (REmake 4)
 * Voiced by (Japanese): Kengo Tsujii (REmake 4)
 * Motion capture: Ryouji Okamoto (RE4, in-game), Munenori Yuo (RE4, cutscenes)

Jack Krauser (ジャック・クラウザー) is the secondary antagonist in Resident Evil 4. He is a freelance mercenary hired by Albert Wesker to infiltrate Saddler's cult. Originally a U.S. government special forces operative, he was partnered with Leon to arrest the South American drug lord Javier Hidalgo. They discover the village suffering a T-Virus outbreak while encountering Manuela Hidalgo who was injected with the T-Veronica virus, Krauser learning of Wesker and the Umbrella conspiracy from Leon. Discharged from the military after his arm was severely injured from fighting Hidalgo, Krauser seeks out Wesker to recover from his injury and become stronger. He later supposedly perished in a helicopter crash. Krauser is responsible for kidnapping Ashley, claiming he committed the act to gain Saddler's trust. He has little interest in Saddler's agenda, and only seeks to recover a Las Plagas sample for Wesker for the latter's plan to restore the then-defunct Umbrella Corporation, believing such would bring order and balance to the world. In addition to being a skilled knife fighter and archer, Krauser possesses superhuman speed, stamina, strength, the dominant variant of Las Plagas injected into his body can turn his left arm into a giant mutated claw. He confronts Kennedy twice in the game's main storyline and is defeated by him, later killed by Ada in the "Separate Ways" scenario. It would be later revealed that Wesker retrieve Krauser's corpse and extracted his Las Plagas after Ada gave him a recessive variant. Krauser is playable in Mercenaries mode. He uses his bow in combat and can also utilize his mutated arm as a melee weapon.

In the 2023 remake of Resident Evil 4, Krauser role is greatly expanded, with several changes made to his background. In the remake, he was a US Army Major and Leon's former mentor and instructor. The game also alters Operation Javier to have been a mission where he was the only survivor, with files indicating the military abandoned him and his men due to an internal power struggle. Unlike the original game, Krauser seemingly joined Los Illuminados on his own accord. He also does not appear to have any association to Wesker or TRICELL.

Excella Gionne

 * Voiced and motion capture performance by Nina Fehren

Excella Gionne is a British-Italian businesswoman who oversees TRICELL's Bio-Weapons program while also being the leader of the conglomerate's African branch, establishing a massive bio-weapons research facility in the Kijuju Autonomous Zone within a former Umbrella facility while regrouping a bio weapons dealer named Ricardo Irving to provide her with funding for the Uroboros Project she developed with Wesker. However, despite her love and loyalty to Wesker, he infects her with the Uroboros in an act of betrayal. With her body unable to stabilize the virus, she mutates into Uroboros Aheri while absorbing a pile of corpses to increase in size before Chris and Sheva manage to kill the creature.

Mother Miranda

 * Voiced by (English) and motion capture performance: Michelle Lukes
 * Voiced by (Japanese): Sayaka Kinoshita

Mother Miranda is the main antagonist of Resident Evil Village, a scientist who was born in an Eastern European village in the late 19th century and lost her daughter Eva during the Spanish flu pandemic. While entering a cave with the intent of following her daughter in death, a despondent Miranda is infected while coming across a fungal superorganism called the "Megamycete" within the cave that granted her immortality, the ability to assume the form of others, and the collective knowledge of those the fungus came in contact with prior. Miranda uses her gained abilities to experiment on the villagers for years, creating the Cadou parasites in failed attempts to create an ideal vessel to revive Eva in. Miranda is later revealed to be the mentor of Umbrella Corporation founder Oswell E. Spencer and inspired him to achieve his vision of human evolution, making Miranda the indirect instigator of all the major events that transpire in the series. She also provided her assistance to the Connections by providing them the means to create Eveline, later learning of Rosemary Winters from them as she abducts the infant so she can resurrect her daughter. She is ultimately killed by Ethan who rescues Rosemary from her before sacrificing himself to destroy the Megamycete. Miranda also appears in the game's Shadows of Rose DLC, where it's revealed her consciousness survived in the Megamycete's realm. During the events, she lures Rose into the realm to resume her plans, tricking her into depowering for her success. However, Ethan, having also survived in the realm, helps Rose escape and battle Miranda, resulting in her permanent death. She is based on witches.

Alcina Dimitrescu
Alcina Dimitrescu is the matriarch of House Dimitrescu. She serves as one of the four lords of the village and the owner of Castle Dimitrescu. Both she and her daughters are based on vampires.

Dimitrescu Daughters

 * Voiced by (English) and motion capture performance: Bekka Prewitt (Bela), Jeanette Maus (Cassandra), Nicole Tompkins (Daniela)

The Daughters of Alcina Dimitrescu are three women "adopted" by the lady and reside in Castle Dimitrescu. The trio are three human/blowfly hybrids created by their "mother" through experiments with the Cadou, granting them similar abilities to her. However, their nature renders them vulnerable to harm in colder temperatures. Bela is calm, level-headed and rather calculative. Cassandra is more reckless and sadistic of the trio, delighting in torture and painful deaths for her victims. Daniela is the quieter, but most seductive of the group. The daughters each fight Ethan Winters as he searches the castle for his daughter Rose, each confronting him alone in certain areas of the castle. They are each killed when he exploits their weakness to make them vulnerable to his attacks. The daughters are heavily influenced by vampires, specifically the Brides of Dracula.

Donna Beneviento

 * Voiced by (English): Andi Norris (Donna), Paula Rhodes (Angie)
 * Motion Capture: Andi Norris (As Donna herself)
 * Voiced by (Japanese): Miyuki Sato

Donna Beneviento is the matriarch of House Beneviento and one of the four Lords of the Village. Horribly disfigured since birth, Donna went into solitude after the death of her parents, residing in a lone estate north of the village. Through the Cadou experiments conducted on her by Mother Miranda, Donna is granted the ability to manipulate her dolls as extensions of herself and induce hallucinations through Cadou-infected pollen. She is rarely seen without her bride doll Angie, whom she usually speaks through. Entrusted with Rose's legs, Donna is the second of the Village Lords fought by Ethan, subjecting him to nightmarish hallucinations before he escapes and stabs her to death. She is based on Ghosts due to her "possession" of dolls and having a well in her home, referencing The Ring.

Salvatore Moreau

 * Voiced by (English) and motion capture performance: Jesse Pimentel
 * Voiced by (Japanese): Taisuke Nishimura

Salvatore Moreau is the patriarch of House Moreau and one of the Four Lords in Resident Evil Village. Taking residence in the windmills near the reservoir, he is granted aquatic abilities by Miranda's Cadou yet is hideously mutated with his body slightly unstable. Moreau is the least respected of the lords despite his utmost devotion towards Miranda. Ethan encounters him to recover Rose's arms, but Salvatore traps him within the reservoir's area and patrols the area in his more monstrous form. Ethan drains the site to battle Salvatore on the dried-up bed, during which he is killed. Though not based on gothic-horror, he might be based on the Gill-man from the Creature from the Black Lagoon, his last name is also a reference to the 1896 novel, The Island of Doctor Moreau due to him creating the Lycans just like the titular character created Human–animal hybrids.

Karl Heisenberg

 * Voiced by (English) and motion capture performance: Neil Newbon
 * Voiced by (Japanese): Hiroshi Shirokuma

Karl Heisenberg is one of the four lords of Resident Evil Village and the owner of a factory located west of the Village. Through experiments conducted on him with the Cadou, he is granted superhuman strength along with harnessing electromagnetism from the electric organs connected to his nervous system. Unlike the other lords, Heisenberg is more rebellious and actively plots to overthrow Miranda for experimenting on him. He is the last of the village lords Ethan faces, though he initially hands over Rose's torso willingly to help Ethan access his factory. Claiming Miranda has been using him to eliminate the other Lords, Heisenberg proposes an alliance with Ethan to use his daughter to kill her. When he refuses, Heisenberg locks him into his factory to be killed by Soldat experiments. With help from Chris Redfield, Ethan battles a heavily cyber-mutated Heisenberg and kills him in a metal-polymer tank. He is based on Dr. Frankenstein.

Shubhankar Parijat of Gamingbolt has said that Heisenberg is an "outstanding character" and one of the best villain in the series. He described him as the star in the Resident Evil Village, and said that "watching him control metal with his mind like he’s Magneto and use his powers to capture Ethan lets you know early on that Heisenberg’s got some incredible powers- and things only get better from there." But, was disappointed when the character died from the game. Meanwhile, Robert Zak said that Heisenberg was the most overlooked villain, particularly the meme appeal on Lady Dimitrescu. He further said that "he is a more significant and complex character in the story than Lady Dimitrescu, and every bit the badass that she is, yet ever since fans first caught sight of the giantess, he's been lower in the pecking order for both fans and Capcom."

Matthew Bryd of Den of Geek has said that his appearance resembles like Van Helsing and was said to be giving off as a big villain vibe. Wireframe has said that most part of the game plays like its star villain, Heisenberg. He calls him as "a volatile beast with a brutal streak and boisterous, irresistible charm".

Ashley Graham

 * Voiced by (English): Carolyn Lawrence (RE4)
 * Voiced by (Japanese): Akari Kitō (REmake 4)
 * Motion capture: Yukiko Saitani (RE4), Ella Freya (REmake 4)

Ashley Graham (アシュリー・グラハム) is the new U.S. President's daughter in Resident Evil 4. A college student living in Massachusetts, Ashley is abducted by a mysterious cult while attempting to return to her home. She is taken to a remote part of Spain and held captive in a village inhabited by humans infected with mind-controlling parasites. The cult's leader, Osmund Saddler, plans to infect her with Las Plagas, to carry out the cult's secret agenda. She is rescued by Kennedy, and works alongside him to thwart the cult's plans and escape. In addition to being able to receive commands and perform simple tasks, Ashley briefly becomes a playable character for a portion of the game.

Baker family
The Baker family, under the influence of the B.O.W. Eveline, are the main antagonists of Resident Evil 7: Biohazard. Unlike the rest of her family, Zoe Baker is a supporting character who provides assistance to the main character Ethan Winters. A member of the extended family, Joe Baker, is the player character of its post-launch DLC End of Zoe.

Clancy Javis

 * Voiced by (English): Tony Vogel (RE7)
 * Voiced by (Japanese): Yu Seki (RE7)

Clancy Javis is a playable character from Resident Evil 7: The Beginning Hour. He enters the Bakers' residence with Andre Stickland and Peter Walken to film an episode of Sewer Gators. He is briefly a playable character while filming Peter. Clancy then searches for Andre who wanders away from the group but is knocked unconscious after discovering Andre's corpse. Later, Clancy was tied up and taken into a game room by Lucas who dares him to solve various puzzles in order to light the candle and put it on the cake. When Clancy removed the turner from the barrel, the oil leaks out. After various puzzles, he lights a birthday cake which suddenly exploded, causing him to be engulfed in flames, killing him in the process.

Clancy also appears in the Banned Footage DLC for the game, a collection of stories that take place before the events of the game. In "Nightmare", Clancy is forced to contend with seemingly endless waves of Molded throughout a night, eventually facing Jack in combat. In "Bedroom", he tries to escape the master bedroom of the house whilst being monitored by Marguerite. In "21", Clancy is forced to play a card game against another victim of the Bakers, Hoffman, by Lucas, eventually beating him and leading to Hoffman's death. His success leads to Lucas placing him in the Happy Birthday death trap.

Daniel Cortini
Daniel Cortini is a minor character in the Resident Evil 2 remake. The sheriff of Arklay county, he takes part holding back the T-virus outbreak in the Raccoon City area. Whilst investigating a gas station near the city, Daniel is killed by a zombie after being distracted by the arrival of either Leon or Claire. He appears as a playable protagonist in The Ghost Survivors DLC chapter "No Way Out", which is unlockable after completing the other chapters. A non-canonical account, Daniel battles a large number of enemies in a gas station until he can be rescued.

Deborah Harper

 * Voiced by (English): Kate Higgins (RE6)
 * Motion capture: Lauren Kim (RE6)

Deborah Harper is the younger sister of Helena Harper. In the past, Helena was known to be very protective towards Deborah, having wounded Deborah's abusive ex-boyfriend. In Resident Evil 6, the two sisters were held as hostages by Derek C. Simmons in the secret lab underneath the Tall Oaks Cathedral. Helena tried her best to keep a terrified Deborah calm and assures her. Helena offered herself to Simmons in exchange for her sister, but her pleas did nothing and Deborah was dragged away. Deborah was later taken to the catacombs of the cathedral, and was injected with C-virus; however, as she showed no signs of mutation, Deborah was left to die. After Helena and Leon rescue Deborah, they soon arrive at the lower levels of the catacombs, where Deborah becomes very ill before bursting into flames; a goo then hardens into a cocoon around her. As the lower levels then begin to crumble, Deborah emerges with spider-like appendages on her back. Despite Helena's pleas not to harm her sister, Ada reminds her that Deborah has to be killed or else they will die. After the battle, Helena grabs Deborah as she slips and falls over a pit. She then begs for forgiveness, saying she will avenge her sister after she and Leon kill Simmons, and releases Deborah as she falls to her death into the darkness below. At the end of Leon and Helena's campaign, Helena visits Deborah's grave at a cemetery.

Lisa Trevor

 * Played by: Marina Mazepa (Welcome to Raccoon City), Casey B. Dolan (Netflix's Resident Evil)

Lisa Trevor (リサ・トレヴァー) is a character and enemy in the remake of Resident Evil and The Umbrella Chronicles. Lisa Trevor is the daughter of George Trevor, the architect behind Ozwell Spencer's Arklay Mansion and the Queen Zenobia cruiser, and his wife Jessica. Following the completion of the mansion's construction, Spencer invites the family to stay there, but betrays George by kidnapping Jessica and Lisa and uses them as human test subjects for genetic experimentation. George is also forced to try to escape the mansion, eventually getting lost and dying of malnutrition. Lisa undergoes a series of painful experiments, including receiving the Progenitor virus, while her mother is secretly murdered. Lisa emerges with a grotesque and twisted physical appearance, but gains enhanced strength and nigh-invincibility. Further experimentation on Lisa allows Umbrella's top scientists, William Birkin and Albert Wesker, to develop the G-virus. Lisa is then executed and buried, but she survives and hides in the Arklay forest. She encounters STARS operatives during the events of Resident Evil before ultimately finding her mother's corpse, granting her some closure. Lisa makes her final appearance in The Umbrella Chronicles, where she is defeated by Wesker and left to die as the Arklay mansion and research facility self-destruct.

In 2012, IGN ranked as the ninth best boss in the series, adding, "Not only can her wails be heard throughout the game, she effectively can't be killed – only deterred. Few things are scarier than that, making her one of the more memorable and entrenched characters in the series."

In the reboot film Resident Evil: Welcome to Raccoon City (2021), Trevor is played by Marina Mazepa. Trevor also appeared in the fifth episode of the Netflix television series (2022), played by Casey B. Dolan.

Luis Sera

 * Voiced by (English): Rino Romano (RE4), André Peña (REmake 4)
 * Voiced by (Japanese): Kenjiro Tsuda (REmake 4)
 * Motion capture: Keiichi Wada (RE4), André Peña (REmake 4)

Luis Sera Navarro (ルイス・セラ・ナヴァッロ) is a Spanish investigator who tries to assist Leon S. Kennedy and Ada Wong in their efforts against Los Illuminados during the events of Resident Evil 4 (2005), having worked with the cult's leader Osmund Saddler to research and develop their mind-controlling parasites, Las Plagas, before realizing their true intentions. While working with Leon, Luis claims he is a former policeman from Madrid who became dissatisfied with his job. Seeing the Las Plagas outbreak as his fault, Luis aids Leon in eliminating it until he is killed by Saddler.

Luis also appears in the 2023 remake, though his role in the game is expanded on, including his expanded past and full name. His backstory further reveals that he was also the former Umbrella Corporation's researcher prior to working for Los Illuminados, with the files revealing he was involved in the creation of the Nemesis. It is also indicated that Luis grew up in the village, though left after his grandfather died from an injury sustained in a wolf attack (suggested to have been under the result of a Plaga infection). Luis assists Leon in several additional sections, such as escaping the mines underneath Salazar's castle. Unlike the original game, he is killed by Jack Krauser rather than Saddler.

Mia Winters

 * Voiced by (English) and motion capture performance: Katie O'Hagan
 * Voiced by (Japanese): Akari Higuchi
 * Face model: Savannah Daniels

Mia is the spouse of Ethan Winters, the main character in Resident Evil 7: Biohazard. A researcher for a criminal organization called The Connections, Mia was tasked with escorting a bio-weapon called Eveline to another facility. But the tanker crashes in a Louisianan swamp during a hurricane, with Mia infected by Eveline as they end up with the Baker family. As the result of her infection, Mia lashes out at Ethan when he came looking for her. From that point on, Mia works with a woman called Zoe (who is revealed to be a Baker) and Ethan tries to save them by receiving hints from Zoe when she telephones him, while Ethan is having to deal with constant attacks perpetrated by the other Bakers. After using one of the two serums Zoe created to kill Jack Baker, Ethan used the remaining vial on Mia as they are forced to leave Zoe behind. The two end up at the remains of the tanker, Mia regaining her memories while resisting Eveline to give Ethan samples from Eveline to develop a toxin to kill her with. She is reunited with Ethan after being rescued by BSAA agents, later giving birth to Rosemary while not telling Ethan the truth that he was infected with the Mold as they moved to Eastern Europe.

In the events of Resident Evil Village, Mia is abducted by her former colleague Miranda, who assumed her identity to steal Rose as a vessel for her lost child Eva. Mia ends up being rescued by Chris and revealing Ethan's altered nature when told that Jack Baker killed him. After Ethan permanently died destroying the megamycete, Mia raised Rosemary while Chris would later train the girl in using her abilities.

Natalia Korda

 * Voiced by (English): Gabriella Pastore (Revelations 2)
 * Voiced by (Japanese): Aoi Yūki (Revelations 2)

Natalia Korda is a playable character in Resident Evil: Revelations 2. A young survivor of the Terragrigia panic who lost her parents in the incident, she was saved by Neil Fisher and placed in a home before she was among those he abducts for Alex Wesker's selection experiment to transfer a copy of her mind into an ideal host able to suppress their fear. Natalia traveled with Claire and Moira before Neil spirits her away when Alex decides to make the girl her host, placing her in a deep sleep for the process before committing suicide.

Awakening six months later, with the copy of Alex's mind appearing before her as Dark Natalia while looking for her teddy bear Lottie, Natalia meets Barry Burton immediately when he arrives on an island to search for Moira. Natalia aids Barry by detecting monsters, go through small passageways, and using bricks as projectiles when not evading monsters. But Natalia is stalked by Alex, who mutated and survived her suicide with a maddened resolve to kill the girl before she fully awakens as her copy. Barry adopts Natalia following the ordeal, with the copy of Alex's mind appearing to be taking over as Natalia reads a piece by Franz Kafka while smiling.

Robert Kendo

 * Voiced by (English): Gary Krawford (RE2), Jason C. Miller (The Darkside Chronicles), Ken Lally (REmake 2, REmake 3)
 * Motion Capture Performance by: Ken Lally (REmake 2 ), Neil Newbon (REmake 3)
 * Voiced by (Japanese): Hideki Tanaka (REmake 2, REmake 3)

Robert Kendo is the owner of a gun store in Raccoon City. He and his brother Joseph are responsible for creating the Samurai Edge pistols used by S.T.A.R.S. members. In the original Resident Evil 2, he briefly appears in the opening of Scenario A, allowing the player to stay in his gunshop for protection. However, zombies soon break in and devour Kendo, leaving a weapon for the player to pick up. In the remake, Robert had brief reunion with Jill, before confronting Leon S. Kennedy and Ada Wong when the two latter attempt to pass through the shop to reach the sewers. It's also revealed he has a daughter, Emma, who he tries to protect from the outbreak. However, she is infected and Robert is forced to kill her. Kendo also appears in the game's The Ghost Survivors DLC as the player character in "No Time to Mourn". A non-canonical scenario, it follows him as he attempts to escape Raccoon City. He also appears in The Darkside Chronicles, though is killed offscreen before he encounters either Leon or Claire.

Steve Burnside

 * Voiced by: Bill Houston (Code: Veronica), Sam Riegel (The Darkside Chronicles)

Steve Burnside (スティーブ・バーンサイド) is Claire Redfield's partner in the game Resident Evil – Code: Veronica. Steve was imprisoned in the Rockfort Island's facility alongside his father, a former Umbrella employee. He escapes from his cell during the viral outbreak. Steve was initially hesitant to trust Claire while reluctantly cooperating with her, but gradually cares for her after being forced to kill his own father when he becomes infected. Steve and Claire eventually end up in Umbrella's Antarctic Facility, where he is captured by Alexia and infected with the T-Veronica virus to be compelled to kill Claire. Though he mutated into a nearly invulnerable monster armed with a giant, ceremonial axe, Steve eventually regained control of himself and is fatally injured protecting Claire from Alexia's tentacles and reverts while professing his love to Claire in his final moments. Steve's body was later taken by Wesker to extract the T-Veronica virus. In The Darkside Chronicles it is revealed that Wesker contacted the drug baron Javier Hidalgo and took a sample of T-Veronica from Steve's corpse in order to sell the virus for Hidalgo's ailing daughter, Manuela.

The Duke

 * Voiced by (English): Aaron LaPlante

The Duke is a merchant and vendor in Resident Evil Village. An obese and mysterious figure, he sells items, weapons and upgrades to the player. The Duke also buys treasures and items, and will cook meals in return for the needed ingredients. The Duke helps Ethan traverse the titular village and helps him recover Rose's body parts from the Four Lords. After Ethan is mortally injured by Miranda, the Duke recovers his body and takes him to the ritual site to confront her. Like the Merchant from Resident Evil 4, the Duke's past and history remains mysterious, though files indicate that he sells objects and provisions to the entire village, including forbidden items. The Duke also appears to relocate without being detected and set up shop within three of the Four Lords' territory (except House Beneviento because Ethan's weapons had been taken). When Ethan returns to the ceremonial site after killing Donna and Moreau, he can be seen observing a Miss Madalina doll and a jar of a Cadou Parasite. A corrupted version of the Duke, referred to as the "Masked Duke", appears in the game's DLC chapter Shadows of Rose. Files in the game reveal this version to be a construct of the Megamycete created by Mother Miranda. The Masked Duke serves as an enemy to Rose Winters as she searches for a crystal to remove her powers at a recreation of Castle Dimitrescu.

The Merchant

 * Voiced by (English): Paul Mercier (RE4) Michael Adamthwaite (REmake 4)
 * Voiced by (Japanese): Shigeru Chiba (REmake 4)

The Merchant is a mysterious hooded vendor in Resident Evil 4. Appearing in certain areas of the games locations, he sells to the player character in return for Peseta. The Merchant can also sell upgrades, including those to weapons and storage capacity, and buy treasures and items. While playing as Leon, the Merchant will set the player a number of optional quests, such as a shooting range or destruction of blue medallions around the village. The Merchant also returns in the remake, where he offers other features such as requests to complete, trading objects for spinels and repairing Leon's equipment. He is also mentioned in passing by the Duke in Village, who directly quotes him.