List of South American animals extinct in the Holocene

This is a list of South American animals extinct in the Holocene that covers extinctions from the Holocene epoch, a geologic epoch that began about 11,650 years before present (about 9700 BCE) and continues to the present day.

The list includes animal extinctions in the Galápagos, Falklands, and other islands near the continent. Extinct animals from the West Indies are covered in List of Antillian and Bermudan animals extinct in the Holocene. Extinctions from Easter Island, a territory of Chile in Polynesia, are covered in the List of Oceanian species extinct in the Holocene.

Many extinction dates are unknown due to a lack of relevant information.