List of The New York Times number-one books of 2021

The American daily newspaper The New York Times publishes multiple weekly lists ranking the best-selling books in the United States. The lists are split in three genres—fiction, nonfiction and children's books. Both the fiction and nonfiction lists are further split into multiple lists.

Fiction
The following list ranks the number-one best-selling fiction books, in the combined print and e-books category.

The most frequent weekly best seller of the year was The Four Winds by Kristin Hannah with 5 weeks at the top of the list, followed closely by The Duke and I by Julia Quinn with 4 weeks.

Nonfiction
The following list ranks the number-one best-selling nonfiction books, in the combined print and e-books category.