List of adverse effects of paroxetine

This is a list of adverse effects of the antidepressant paroxetine, sorted by frequency of occurrence.

Very common
Very common (10-100% incidence) adverse effects include:
 * Nausea
 * Sexual dysfunction (including anorgasmia (difficulty achieving an orgasm), erectile dysfunction, genital anaesthesia, ejaculation disorder, loss of libido etc.). Paroxetine is associated with a higher rate of sexual dysfunction than other SSRIs.
 * Impaired concentration
 * Somnolence is more common with paroxetine than with other SSRIs.
 * Insomnia
 * Headache
 * Dry mouth

Common
Common (1-10% incidence) adverse effects include:


 * Changes in appetite
 * Dyspepsia (indigestion)
 * Tooth disorder
 * Stomatitis
 * Oropharyngeal disorder
 * Flatulence
 * Impaired urination
 * Urinary frequency
 * Agitation
 * Abnormal dreams (including intense dreams or nightmares)
 * Hypercholesterolaemia (elevated blood cholesterol)
 * Dizziness
 * Tremor
 * Blurred vision
 * Yawning
 * Diarrhoea which is less common with paroxetine than with other SSRIs.
 * Constipation (if chronic may lead to hemorrhoids)
 * Vomiting
 * Anxiety
 * Nervousness
 * Hypomania,   may occur in as many as 8% of patients being treated with paroxetine. May be more common in those with bipolar disorder.
 * Asthenia
 * Weight gain or loss. Usually gain, paroxetine tends to produce more weight gain than other SSRIs.
 * Confusion
 * Emotional lability
 * Myoclonus
 * Myopathy
 * Myalgia
 * Myasthenia
 * Drugged feeling
 * Hyperthesia
 * Respiratory disorder
 * Pharyngitis
 * Increased cough
 * Rhinitis
 * Taste perversion
 * Abnormal vision
 * Pruritus (itching)
 * Sweat gland disorder
 * Abdominal pain
 * Fever
 * Chest pain
 * Trauma
 * Back pain
 * Malaise
 * Pain
 * Palpitations
 * Vasodilatation
 * Postural hypotension (a drop in blood pressure upon standing up)
 * Hypertension (high blood pressure)
 * Syncope (fainting)
 * Tachycardia (high heart rate)

Uncommon
Uncommon (0.1-1% incidence) adverse effects include:


 * Abnormal bleeding, predominantly of the skin and mucous membranes (mostly ecchymosis)
 * Confusion
 * Hallucinations
 * Extrapyramidal disorders (which occurs more commonly in paroxetine-treating patients than patients treated with other SSRIs)
 * Sinus tachycardia
 * Transient changes in blood pressure
 * Urinary retention
 * Urinary incontinence
 * Allergic reaction
 * Chills
 * Face oedema
 * Infection
 * Bradycardia
 * Conduction abnormalities
 * Abnormal ECG
 * Hypotension
 * Ventricular extrasystoles
 * Acne
 * Alopecia (hair loss)
 * Dry skin
 * Eczema
 * Furunculosis
 * Herpes simplex
 * Urticaria
 * Bruxism
 * Buccal cavity disorders
 * Dysphagia
 * Eructation
 * Gastroenteritis
 * Gastrointestinal flu
 * Glossitis
 * Increased salivation
 * Abnormal liver function tests
 * Mouth ulceration
 * Rectal haemorrhage
 * Miscarriage
 * Amenorrhoea (lack of menstrual cycles)
 * Breast pain
 * Cystitis
 * Dysmenorrhoea
 * Dysuria
 * Menorrhagia
 * Nocturia
 * Polyuria
 * Urinary tract infection
 * Urinary urgency
 * Vaginitis
 * Anaemia
 * Leucopenia
 * Lymphadenopathy
 * Purpura
 * White blood cell abnormality
 * Oedema
 * Hyperglycaemia (high blood sugar)
 * Peripheral oedema
 * Thirst
 * Arthralgia
 * Arthritis
 * Traumatic fracture
 * Abnormal thinking
 * Akinesia
 * Alcohol use disorder
 * Amnesia (memory loss)
 * Ataxia
 * Convulsion
 * Lack of emotion
 * Paranoid reaction
 * Asthma
 * Bronchitis
 * Dyspnoea (air hunger)
 * Epistaxis
 * Hyperventilation
 * Pneumonia
 * Respiratory flu
 * Sinusitis
 * Abnormality of accommodation
 * Conjunctivitis
 * Ear pain
 * Eye pain
 * Mydriasis
 * Otitis media
 * Tinnitus
 * Keratoconjunctivitis

Rare
Rare (0.01-0.1% incidence) adverse effects include:


 * Mania, may be more common in those that either have or have a family history of bipolar disorder.
 * Depersonalisation
 * Panic disorder
 * Akathisia
 * Restless legs syndrome
 * Elevated liver enzymes
 * Hyperprolactinaemia (elevated serum prolactin)
 * Galactorrhoea (lactation that is not associated with pregnancy or breastfeeding)
 * Abnormal laboratory value
 * Abscess
 * Adrenergic syndrome
 * Cellulitis
 * Chills and fever
 * Cyst
 * Hernia
 * Intentional overdose
 * Neck rigidity
 * Pelvic pain
 * Peritonitis
 * Substernal chest pain
 * Ulcer
 * Angina pectoris
 * Arrhythmia
 * Atrial arrhythmia
 * Atrial fibrillation
 * Bundle branch block
 * Cerebral ischaemia
 * Cerebrovascular accident (stroke)
 * Congestive heart failure
 * Extrasystoles
 * Low cardiac output
 * Myocardial infarct (heart attack)
 * Myocardial ischaemia
 * Pallor
 * Phlebitis
 * Pulmonary embolus
 * Supraventricular extrasystoles
 * Thrombophlebitis
 * Thrombosis
 * Varicose vein
 * Vascular headache
 * Angioedema
 * Contact dermatitis
 * Erythema nodosum
 * Herpes zoster
 * Hirsutism
 * Maculopapular rash
 * Photosensitivity
 * Skin discolouration
 * Skin ulcer
 * Diabetes mellitus
 * Hyperthyroidism
 * Hypothyroidism
 * Thyroiditis
 * Aphthous stomatitis
 * Bloody diarrhoea
 * Bulimia
 * Colitis
 * Duodenitis
 * Oesophagitis
 * Faecal impaction
 * Faecal incontinence
 * Gastritis
 * Gingivitis
 * Haematemesis (vomiting blood)
 * Hepatitis
 * Ileus
 * Jaundice
 * Melaena (black faeces as a result of bleeding in the stomach)
 * Salivary gland enlargement
 * Stomach ulcer
 * Stomatitis
 * Tongue oedema
 * Tooth caries
 * Tooth malformation
 * Breast atrophy
 * Female lactation
 * Haematuria (blood in the urine)
 * Kidney calculus (kidney stones)
 * Abnormal kidney function
 * Kidney pain
 * Mastitis
 * Nephritis
 * Oliguria
 * Urethritis
 * Urine abnormality
 * Vaginal candidiasis
 * Eosinophilia
 * Iron deficiency anaemia
 * Leucocytosis
 * Lymphoedema
 * Lymphocytosis
 * Microcytic anaemia
 * Monocytosis
 * Normocytic anaemia
 * Increased alkaline phosphatase
 * Bilirubinaemia
 * Dehydration
 * Gout
 * Hyperphosphataemia (elevated levels of phosphate in the blood)
 * Hypocalcaemia (low blood calcium)
 * Hypoglycaemia (low blood sugar)
 * Hypokalaemia (low blood potassium)
 * Hyponatraemia (low blood sodium)
 * Obesity
 * Arthrosis
 * Bursitis
 * Cartilage disorder
 * Myositis
 * Osteoporosis (brittle bones)
 * Tetany
 * Abnormal electroencephalograph
 * Abnormal gait
 * Choreoathetosis
 * Circumoral paraesthesia
 * Delirium
 * Delusions
 * Diplopia
 * Drug dependence
 * Dysarthria
 * Euphoria
 * Fasciculations
 * Grand mal convulsions
 * Hyperalgesia
 * Hysteria
 * Increased libido
 * Manic depressive reaction
 * Meningitis
 * Myelitis
 * Neuralgia
 * Neuropathy
 * Nystagmus
 * Psychosis
 * Psychotic depression
 * Increased reflexes
 * Stupor
 * Withdrawal syndrome
 * Hiccup
 * Lung fibrosis
 * Increased sputum
 * Voice alteration
 * Emphysema
 * Pulmonary oedema
 * Amblyopia
 * Specified cataract
 * Conjunctival oedema
 * Corneal lesion
 * Corneal ulcer
 * Exophthalmos
 * Eye haemorrhage
 * Glaucoma
 * Hyperacusis
 * Otitis externa
 * Photophobia
 * Retinal haemorrhage (bleeding into the retina)
 * Taste loss
 * Anisocoria
 * Deafness
 * Activation syndrome

Very rare
Rare (<0.01% incidence) adverse effects include:
 * Thrombocytopenia
 * Syndrome of inappropriate secretion of antidiuretic hormone (SIADH)
 * Serotonin syndrome (symptoms may include agitation, confusion, diaphoresis, hallucinations, hyperreflexia, myoclonus, shivering, tachycardia and tremor)
 * Gastrointestinal bleeding
 * Hepatic events (such as hepatitis, sometimes associated with jaundice and/or liver failure)
 * Priapism
 * Severe cutaneous adverse reactions (including erythema multiforme, Stevens–Johnson syndrome and toxic epidermal necrolysis)
 * Photosensitivity reactions