List of adverse effects of valproate semisodium

Adverse effects by frequency for use of valproate semisodium.

Very common (>10% frequency)

 * Nausea
 * Tremor

Common (1-10% frequency)

 * Liver injury
 * Gastralgia
 * Diarrhoea
 * Extrapyramidal (movement) disorder
 * Stupor
 * Somnolence
 * Convulsion
 * Memory impairment
 * Headache
 * Nystagmus
 * Confusional state
 * Aggression
 * Agitation
 * Impaired attention
 * Hyponatraemia
 * Anaemia
 * Thrombocytopaenia
 * Hypersensitivity
 * Transient and/or dose-related hair loss
 * Dysmenorrhea
 * Haemorrhage (bleeding)
 * Weight gain

Uncommon (0.01-0.1% frequency)

 * Pancreatitis (sometimes lethal)
 * Coma
 * Lethargy
 * SIADH
 * Pancytopenia
 * Leucopenia
 * Rash
 * Angioedema
 * Amenorrhoea (absence of menstrual cycle)
 * Vasculitis
 * Peripheral oedema
 * Reduced bone mineral density
 * Osteopaenia
 * Osteoporosis
 * Pleural effusions
 * Gingival enlargement


 * Phasmophobia

Rare (<0.01% frequency)

 * Reversible dementia
 * Reversible cerebral atrophy
 * Abnormal behaviour
 * Psychomotor hyperactivity
 * Learning disorder
 * Hyperammonaemia
 * Hypothyroidism
 * Bone marrow failure
 * Toxic epidermal necrolysis
 * Stevens–Johnson syndrome
 * Erythema multiforme
 * DRESS syndrome
 * Male infertility
 * Polycystic ovaries
 * Enuresis
 * Reversible Fanconi syndrome
 * Coagulation abnormalities
 * Systemic lupus erythematosus
 * Gynaecomastia