List of banned substances in Major League Baseball

Major League Baseball's drug policy prohibits players from using, possessing, selling, facilitating the sale of, distributing, or facilitating the distribution of any Drug of Abuse and/or Steroid. Any and all drugs or substances listed under Schedule II of the Controlled Substances Act are considered drugs of abuse covered by the Program. Players who require prescription medication can still use it with a "Therapeutic Use Exemption" granted by MLB.

In December 2019, MLB removed cannabinoids and added cocaine and opiates to its list of Drugs of Abuse. However, players were told that they could still be suspended for possessing or selling cannabis, or driving under the influence of cannabis.

==List of banned substances (not exhaustive) ==

Drugs of abuse

 * 1) Synthetic cannabinoids
 * 2) Cocaine
 * 3) LSD
 * 4) Opiates (e.g., fentanyl, oxycodone, heroin, codeine, and morphine)
 * 5) Amphetamines (e.g., MDMA (Ecstasy), MDA, Meth)
 * 6) "Bath salts" (e.g., cathinone, synthetic cathinone, MDPV)
 * 7) GHB
 * 8) Phencyclidine (PCP)

Performance enhancing substances (steroids, growth factors, hormone modulators, masking agents)

 * 1) Androstanediol
 * 2) Androstanedione
 * 3) Androstatrienedione (ATD)
 * 4) Androstanolone
 * 5) Androstenediol
 * 6) Androstenedione
 * 7) Androst-2-en-17-one (2-androstenone, delta-2)
 * 8) Androsterone
 * 9) Bolandiol
 * 10) Bolasterone
 * 11) Boldenone
 * 12) Boldione
 * 13) Calusterone
 * 14) Clenbuterol
 * 15) Clostebol (chlortestosterone)
 * 16) Danazol
 * 17) Dehydrochloromethyltestosterone (DHCMT, turinabol)
 * 18) Dehydroepiandrosterone (DHEA)
 * 19) Desoxy-methyltestosterone (DMT, madol)
 * 20) Dihydrotestosterone
 * 21) Drostanolone
 * 22) Epiandrosterone
 * 23) Epi-dihydrotestosterone
 * 24) Epitestosterone
 * 25) Ethylestrenol
 * 26) Fluoxymesterone
 * 27) Formebolone
 * 28) Furazabol
 * 29) Gestrinone
 * 30) Halodrol
 * 31) 4-Hydroxytestosterone
 * 32) 7-Keto-DHEA
 * 33) Mestanolone
 * 34) Mesterolone
 * 35) Methandienone
 * 36) Methandriol
 * 37) Methasterone (superdrol)
 * 38) Methenolone
 * 39) Methylclostebol
 * 40) Methyldienolone
 * 41) Methylnortestosterone
 * 42) Methylstenbolone (ultradrol, m-sten)
 * 43) Methyltestosterone
 * 44) Methyltrienolone (metribolone)
 * 45) Mibolerone
 * 46) Nandrolone
 * 47) Norbolethone
 * 48) Norandrostenediol
 * 49) Norandrostenedione
 * 50) Norandrosterone
 * 51) Norbolethone (genabol)
 * 52) Norclostebol
 * 53) Norethandrolone
 * 54) Noretiocholanolone
 * 55) Oxabolone
 * 56) Oxandrolone
 * 57) Oxymesterone
 * 58) Oxymetholone
 * 59) Prasterone (DHEA)
 * 60) Promagnon
 * 61) Prostanozol
 * 62) Quinbolone
 * 63) Selective androgen receptor modulators (SARMs)
 * 64) Stanozolol
 * 65) Stenbolone
 * 66) Testosterone
 * 67) Tetrahydrogestrinone
 * 68) Tibolone
 * 69) Trenbolone
 * 70) Zeranol
 * 71) Zilpaterol
 * 72) Any salt, ester, or ether of a drug or substance listed above
 * 73) Human growth hormone (hGH), including all fragments (e.g., AOD9604, hGH fragment 176-191) and releasing factors including GHRHs (e.g., CJC-1295, sermorelin, tesamorelin), GHSs (e.g., ghrelin and its mimetics (e.g., anamorelin, ibutamoren (MK-0677), ipamorelin), and peptides (e.g., alexamorelin, GHRP-2 (pralmorelin), GHRP-6, hexarelin)
 * 74) Insulin-like growth factor (IGF-1), including all isomers of IGF-1 (mechano growth factors, thymosin beta-4)
 * 75) Gonadotrophins (hCG), including LH and hCG
 * 76) Corticotrophins, including releasing factors (corticorelin)
 * 77) Erythropoiesis stimulating agents, including (erythropoietin (EPO), darbepoetin (dEPO), hematide, methoxy polyethylene glycol-epoetin beta (CERA))
 * 78) Aromatase inhibitors, including anastrozole, androstatrienedione (ATD), androstenetrione (6-OXO), aminoglutethimide, arimistane, exemestane, formestane, letrozole, and testolactone
 * 79) Selective estrogen receptor modulators (SERMs), including bazedoxifene, ospemifene, raloxifen, tamoxifen, and toremifen
 * 80) Other Anti-estrogens, including clomiphene, cyclofenil, and fulvestrant
 * 81) Myostatin modifying agents, including myostatin inhibitors (e.g., follistatin)
 * 82) Metabolic modifying agents, including Peroxisome Proliferator Activated Receptor δ (PPARδ) agonists (GW1516, GW501516, GW0742), AMP-activated protein kinase (AMPK) activators (AICAR, SR9009 (stenabolic)), meldonium (mildronate), trimetazidine
 * 83) HIF stabilizers, including roxadustat (FG-4592), molidustat (BAY 85-3934), FG-2216, BAY 87-2243.
 * 84) Masking agents, including diuretics, desmopressin, probenecid, plasma expanders (e.g., intravenous administration of albumin, dextran, hydroxyethyl starch and mannitol)
 * 85) Diuretics include acetazolamide, amiloride, bumetanide, canrenone, chlorthalidone, etacrynic acid, furosemide, indapamide, metolazone, spironolactone, thiazides (e.g., bendroflumethiazide, chlorothiazide, hydrochlorothiazide), triamterene, vaptans
 * 86) Gene doping, the use of nucleic acids that may alter genome sequences and/or gene expression, including gene editing, gene silencing, gene transfer, genetically modified cells

Stimulants

 * 1) Adrafinil
 * 2) Amfepramone (diethylproprion)
 * 3) Amiphenazole
 * 4) Amphetamine
 * 5) Amphetaminil
 * 6) Armodafinil
 * 7) Benfluorex
 * 8) Benzphetamine
 * 9) Benzylpiperazine
 * 10) Bromantan
 * 11) Carphedon
 * 12) Cathine (norpseudoephedrine)
 * 13) Chloroamphetamine
 * 14) Clobenzorex
 * 15) Cropropamide
 * 16) Crotetamide


 * 1) Dimethylamylamine
 * 2) Dimethylamphetamine
 * 3) 1,3-Dimethylbutylamine (DMBA)
 * 4) Ephedrine
 * 5) Etamivan
 * 6) Ethylamphetamine
 * 7) Etilefrine
 * 8) Famprofazone
 * 9) Fenbutrazate
 * 10) Fencamfamine
 * 11) Fenethylline
 * 12) Fenfluramine
 * 13) Fenproporex
 * 14) Furfenorex
 * 15) Heptaminol
 * 16) Isometheptene
 * 17) Levmetamphetamine
 * 18) Lisdexamphetamine
 * 19) Meclofenoxate
 * 20) Mefenorex
 * 21) Mephentermine
 * 22) Mesocarb
 * 23) Methylephedrine
 * 24) Methylhexaneamine (dimethylamylamine, DMAA)
 * 25) Methylphenidate
 * 26) Modafinil
 * 27) N,alpha-Diethylphenylethylamine (N,a-DEPEA)
 * 28) N-ethyl-1-phenyl-2-butanamine
 * 29) Nikethamide
 * 30) Norfenefrine
 * 31) Norfenfluramine
 * 32) Octodrine (DMHA)
 * 33) Octopamine
 * 34) Oxilofrine
 * 35) Parahydroxyamphetamine
 * 36) Pemoline
 * 37) Pentetrazol
 * 38) Phendimetrazine
 * 39) Phenethylamine
 * 40) Phenmetrazine
 * 41) Phenpromethamine
 * 42) Phentermine
 * 43) Prenylamine
 * 44) Prolintane
 * 45) Propylhexedrine
 * 46) Pyrovalerone
 * 47) Selegiline
 * 48) Sibutramine
 * 49) Strychnine
 * 50) Tuaminoheptane

Prohibited Substances may be added to the list only by the unanimous vote of HPAC, provided that the addition by the federal government of a substance to Schedule I, II, or III will automatically result in that substance being added to the list.