List of corporations with a major presence in Birmingham, Alabama

Corporations headquartered In Birmingham

 * Alabama Power - division of Southern Company
 * American Cast Iron Pipe Company (ACIPCO)
 * Associated Grocers of the Southeast
 * B.L. Harbert International - international construction company
 * Blue Cross and Blue Shield of Alabama
 * Books-A-Million
 * Bradley Arant Boult Cummings LLP
 * Brasfield & Gorrie
 * Buffalo Rock Company
 * Chester's International
 * Coca-Cola Bottling Company, United
 * Birmingham Speed of America, Inc.
 * Diagnostic Health Corporation
 * Drummond Company
 * EBSCO Industries
 * Encompass Health - nation's largest rehabilitative services company
 * Express Oil Change & Tire Engineers
 * Golden Flake
 * Gulf South Conference
 * Harbert Management Corporation
 * Hibbett Sports
 * Hoar Construction
 * Maynard, Cooper & Gale, P.C.
 * McWane
 * Medical Properties Trust
 * Motion Industries
 * Milo's Hamburgers
 * Nucor
 * O'Neal Steel
 * ProAssurance Corporation
 * Protective Life Corporation - insurance provider
 * Regions Financial Corporation
 * Shipt
 * Southeastern Conference - SEC
 * Southern Company Services
 * Southern Family Markets
 * Southern Nuclear - nuclear division of Southern Company
 * Southern Progress Corporation - publisher of Southern Living magazine, owned by Time Warner
 * Southern Research Institute
 * Southwestern Athletic Conference - SWAC
 * Spire Alabama - Spire Energy
 * Surgical Care Affiliates
 * Taziki's Mediterranean Cafe
 * United Investors Life
 * University of Alabama at Birmingham (UAB) college and medical center
 * Vulcan Materials Company - largest aggregates producer

Fortune 500
As of 2023, Birmingham has two Fortune 500 public companies: Regions Financial Corporation and Vulcan Materials Company. Multiple other Birmingham companies rank in the top 1000.

Private companies with revenue over one billion
Several privately held companies headquartered in Birmingham have annual revenues exceeding one billion dollars. These include American Cast Iron Pipe Company, Brasfield & Gorrie, BE&K, Drummond Company, EBSCO Industries, Harbert Management Corporation, McWane, and O'Neal Steel.

Corporations with large operations in Birmingham

 * AT&T (previously BellSouth) - South Central Bell was headquartered in Birmingham; significant operations in the metro area
 * Belk - regional headquarters
 * CVS Caremark Corporation
 * Jack Henry & Associates
 * KBR, Inc. - division headquarters
 * Metavante Corporation
 * Mueller Water Products - administrative headquarters
 * PNC Bank
 * Southern Company
 * State Farm Insurance Companies - regional and operations headquarters
 * SunGard - regional and division headquarters
 * Synovus Financial
 * U.S. Steel Corporation
 * UnitedHealth Group
 * Washington Group International - regional headquarters, RUST headquarters
 * Wells Fargo & Co. - regional headquarters

Corporations defunct or formerly headquartered in Birmingham

 * Alabama National BanCorporation - merged with RBC Bank
 * AmSouth Bancorporation - merged with Regions
 * Big B Drugs - merged with Revco, now part of CVS
 * BioCryst Pharmaceuticals
 * Bruno's Supermarkets
 * CVS Caremark - moved headquarters in 2004
 * Energen Corporation - acquired by Diamondback Energy in 2018
 * Golf Channel - moved production to Orlando
 * Just For Feet - ceased operations in 2004
 * Liberty National Life Insurance Company
 * MedPartners - changed name to Caremark Rx
 * Saks Incorporated - relocated headquarters to New York City after reorganization
 * Sonat, Inc. - merged with El Paso Corporation
 * SouthTrust Corporation - merged with Wachovia
 * Torchmark Corporation - insurance provider
 * Walter Energy, Inc.